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Interindividual variability in imatinib metabolism in human liver microsomes and primary human hepatocytes: Impact of CYP2C8 and CYP3A phenotypes

Drug Metabolism and Disposition(2025)10.1016/j.dmd.2025.100196Source: DataRank Database

Interindividual variability in imatinib metabolism in human liver microsomes and primary human hepatocytes: Impact of CYP2C8 and CYP3A phenotypes is a research paper published in Drug Metabolism and Disposition (2025). On theSindex it has a DataRank of 0.

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Enrichment:Funding (6 grants)Impact (FWCI 0.00)OA: greenTopics (13)IDs (PubMed, PMC, OpenAlex)Annotations (3)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (9)

Pegah Montazeri,Raeanne M. Geffert ORCID,Amanda J. Gerringer ORCID,Tyler Interrante ORCID,Corbin D. Jones ORCID

Live enrichment

PubMed:41455147 PMC:PMC12990092 OpenAlex:https://openalex.org/W4415816161

National Institute of General Medical Sciences

Grant: R35GM143044

National Institutes of Health

Grant: S10OD032350 (2023

National Institutes of Health

Grant: S10RR024595

NIH HHS

Grant: S10 OD032350

University of North Carolina

University of North Carolina at Chapel Hill School of Medicine

FWCI

0.00

Citation Percentile

0.4%

greenLicense: http://www.elsevier.com/open-access/userlicense/1.0/

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12990092/

publisherhttps://api.elsevier.com/content/article/PII:S0090955625095054?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0090955625095054?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.dmd.2025.100196

Fields of Study

Chronic Myeloid Leukemia TreatmentsMyeloproliferative Neoplasms: Diagnosis and TreatmentHematopoietic Stem Cell Transplantation

Keywords

CYP3AImatinibCYP2C8Cytochrome P450PharmacokineticsDrug metabolismMicrosomeCYP2C9Kinase InhibitorInterindividual Variability

Interindividual variability in imatinib metabolism in human liver microsomes and primary human hepatocytes: Impact of CYP2C8 and CYP3A phenotypes

FAIR Checklist

Authors (9)

Funding (6 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)