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Mutation of PXR phosphorylation motif at Ser347 disrupts lipid and bile acid homeostasis in diet-induced metabolic dysfunction–associated steatohepatitis in mice

Drug Metabolism and Disposition(2025)10.1016/j.dmd.2025.100222Source: DataRank Database

Mutation of PXR phosphorylation motif at Ser347 disrupts lipid and bile acid homeostasis in diet-induced metabolic dysfunction–associated steatohepatitis in mice is a research paper published in Drug Metabolism and Disposition (2025). On theSindex it has a DataRank of 0.

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Enrichment:Funding (12 grants)OA: hybridTopics (21)IDs (PubMed, PMC)

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Authors (13)

Zakiyah R. Henry,Rulaiha Taylor ORCID,Bo Kong ORCID,Ill Yang ORCID,Anita Brinker ORCID

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PubMed:41520575 PMC:PMC12975368

US Department of Veterans Affairs

Grant: BX002741

National Institute of General Medical Sciences

Grant: GM135258

National Institute of General Medical Sciences

Grant: GM093854

National Institute of Environmental Health Sciences

Grant: ES007148

National Institute of Environmental Health Sciences

Grant: ES029258

National Institute of Diabetes and Digestive and Kidney Diseases

Grant: DK122725

BLRD VA

Grant: I01 BX002741

NIEHS NIH HHS

Grant: P30 ES005022

NIGMS NIH HHS

Grant: R01 GM135258

NIEHS NIH HHS

Grant: T32 ES007079

National Institutes of Health

Micropalaeontological Society

hybridLicense: cc-by

publisherhttps://doi.org/10.1016/j.dmd.2025.100222

publisherhttps://api.elsevier.com/content/article/PII:S0090955625095315?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0090955625095315?httpAccept=text/plain

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12975368/

Europe_PMChttps://europepmc.org/articles/PMC12975368

MeSH Terms

LiverAnimalsMice, Inbred C57BLHumansMiceFatty LiverBile Acids and SaltsSerinePhosphorylationHomeostasisMutationMaleLipid MetabolismDiet, High-FatPregnane X Receptor

Keywords

PhosphorylationBile acidsLipogenesisPxrMetabolic Dysfunction–associated SteatohepatitisPxr-ki