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Polygenic and transcriptional risk scores identify chronic obstructive pulmonary disease subtypes in the COPDGene and ECLIPSE cohort studies

EBioMedicine(2024)10.1016/j.ebiom.2024.105429Source: DataRank Database

Polygenic and transcriptional risk scores identify chronic obstructive pulmonary disease subtypes in the COPDGene and ECLIPSE cohort studies is a research paper published in EBioMedicine (2024). On theSindex it has a DataRank of 0. It has been cited 4 times.

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Enrichment:Funding (44 grants)Impact (FWCI 1.09)OA: goldTopics (66)IDs (PubMed, PMC, OpenAlex)Annotations (3)SDGs (1)

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Open Access

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Reusable (0/3)

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Authors (26)

Julian Hecker ORCID,John Platig ORCID,Jingzhou Zhang ORCID,Auyon Ghosh ORCID,Katherine Pratte ORCID

Live enrichment

PubMed:39509750 PMC:PMC11570824 OpenAlex:https://openalex.org/W4404116897

NHLBI NIH HHS

Grant: 75N92023D00011

RRD VA

Grant: I01 RX002745

NHLBI NIH HHS

Grant: K08 HL159318

NHLBI NIH HHS

Grant: R01 HL137995

NHLBI NIH HHS

Grant: R01 HL152735

NHLBI NIH HHS

Grant: K08 HL136928

NHLBI NIH HHS

Grant: R01 HL089856

NHLBI NIH HHS

Grant: R01 HL124233

NHLBI NIH HHS

Grant: R01 HL147148

NHLBI NIH HHS

Grant: R01 HL155749

NHLBI NIH HHS

Grant: P01 HL132825

NHLBI NIH HHS

Grant: R01 HL153460

NHLBI NIH HHS

Grant: R01 HL157879

NHLBI NIH HHS

Grant: K25 HL140186

NHLBI NIH HHS

Grant: R01 HL133135

NHLBI NIH HHS

Grant: R01 HL152728

NHLBI NIH HHS

Grant: P01 HL114501

NHLBI NIH HHS

Grant: R01 HL147326

NHLBI NIH HHS

Grant: R01 HL135142

NHLBI NIH HHS

Grant: U01 HL089856

NHLBI NIH HHS

Grant: U01 HL089897

NHLBI NIH HHS

Grant: R01 HL137927

National Institutes of Health

Grant: 5R01HL147326-03

Prospective Health Outcomes and Inflammatory Biomarkers Associated with e-Cigarette Use

National Institutes of Health

Grant: 5I01RX002745-04

Genetics of Osteoarthritis and Joint Replacement Recovery: Key to Precision Rehabilitation

National Institutes of Health

Grant: 5P01HL114501-02

Distinct and Overlapping Pathways of Fibrosis and Emphysema in Cigarette Smokers

National Institutes of Health

Grant: 5R01HL135142-04

Genetic and Genomic Characterization of the Occurrence and Progression of Interstitial Lung Abnormalities

National Institutes of Health

Grant: 5R01HL152735-02

Multi-omic networks associated with COPD progression in TOPMed Cohorts

National Institutes of Health

Grant: 5R01HL124233-02

Using Integrative Genomics To Identify and Characterize Emphysema-Associated eQTL

National Institutes of Health

Grant: 5U01HL089897-13

(1 of 2) Genetic Epidemiology of COPD

National Institutes of Health

Grant: 7K25HL140186-06

Context matters: Network modeling of COPD regulatory variants across tissues and exposures

National Institutes of Health

Grant: 5R01HL133135-03

COPD Susceptibility, Heterogeneity, and Progression: Proteomics and Genetics

National Institutes of Health

Grant: 5R01HL152728-04

Identifying Protein-Protein Network Interactions between COPD Susceptibility Genes

National Institutes of Health

Grant: 1R01HL160008-01

Hepatocyte Growth Factor Signaling and Airspace Maintenance

National Institutes of Health

Grant: 5R01HL162813-03

Uncovering the genetically-driven differential susceptibility to chronic obstructive pulmonary disease and pulmonary fibrosis

National Institutes of Health

Grant: 1U01HL089856-01A1

Genetic Epidemiology of COPD

National Institutes of Health

Grant: 5K08HL136928-04

Multi-omic Subtyping of Chronic Obstructive Pulmonary Disease

National Institutes of Health

Grant: 5R01HL137927-02

Identifying functional variants in COPD GWAS loci

National Institutes of Health

Grant: 5K08HL159318-03

Multi-omic Risk Prediction of Chronic Obstructive Pulmonary Disease in European- and African-Ancestry Populations

National Institutes of Health

Grant: 7R01HL157879-02

COPD SUBTYPES AND EARLY PREDICTION USING INTEGRATIVE PROBABILISTIC GRAPHICAL MODELS R01HL157879

National Institutes of Health

Grant: 1R01HL147148-01

Genetic and Functional Dissection of a Cluster of COPD GWAS Signals on Chromosome 4q

National Institutes of Health

Grant: 1R01HL137995-01A1

Biomarker of Lung Disease in African Americans

National Institutes of Health

Grant: 5R01HG011393-04

Networks Tools to Understand Sex- and Gender-Specific Drivers of Disease

National Institutes of Health

Grant: 5R01HL153460-03

COPD cachexia: deciphering the impact of antioxidants, iron and mitochondrial function using 'omics approaches

National Institutes of Health

Grant: 5P01HL132825-05

Systems Biology of Airway Disease

FWCI

1.09

Citation Percentile

0.8%

Citation Trend

2026

goldLicense: cc-by-nc-nd

journalhttps://doi.org/10.1016/j.ebiom.2024.105429

publisherhttps://doi.org/10.1016/j.ebiom.2024.105429

publisherhttps://api.elsevier.com/content/article/PII:S2352396424004651?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2352396424004651?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/39509750

Fields of Study

Chronic Obstructive Pulmonary Disease (COPD) ResearchGenetic Associations and EpidemiologyChronic Disease Management Strategies0301 basic medicine03 medical and health sciencesHumansPulmonary Disease, Chronic ObstructiveMaleFemaleGenetic Predisposition to DiseaseAgedMiddle AgedMultifactorial InheritanceBiomarkersRisk FactorsCohort StudiesProtein Interaction MapsGene Expression ProfilingDrug RepositioningPolymorphism, Single Nucleotide

MeSH Terms

AgedFemaleHumansMaleMiddle AgedRisk FactorsCohort StudiesBiomarkersGenetic Predisposition to DiseaseMultifactorial InheritancePolymorphism, Single NucleotideGene Expression ProfilingPulmonary Disease, Chronic ObstructiveDrug RepositioningProtein Interaction Maps

Keywords

Pulmonary diseaseCohortMedicineCohort studyInternal medicineEclipseDiseaseBioinformaticsOncologyBiologyCOPDTranscriptomicsDrug RepurposingPolygenic Risk ScoresEndotypingMaleMultifactorial InheritanceGene Expression ProfilingDrug RepositioningArticlesMiddle AgedPolymorphism, Single NucleotideCohort StudiesPulmonary Disease, Chronic ObstructiveRisk FactorsHumansFemaleGenetic Predisposition to DiseaseProtein Interaction MapsBiomarkersAged

Sustainable Development Goals

SDG 0: Good health and well-being

Polygenic and transcriptional risk scores identify chronic obstructive pulmonary disease subtypes in the COPDGene and ECLIPSE cohort studies

FAIR Checklist

Authors (26)

Funding (44 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)