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Safety and toxicity of Iopofosine I 131 (CLR 131) with external beam radiation therapy in recurrent or metastatic head and neck cancer: results of a phase 1 single-centre, open-label, single-arm, dose escalation and dose expansion study

EBioMedicine(2024)10.1016/j.ebiom.2024.105496Source: DataRank Database

Safety and toxicity of Iopofosine I 131 (CLR 131) with external beam radiation therapy in recurrent or metastatic head and neck cancer: results of a phase 1 single-centre, open-label, single-arm, dose escalation and dose expansion study is a research paper published in EBioMedicine (2024). On theSindex it has a DataRank of 0.228. It has been cited 3 times, with 3 citing works in its 1-hop citation network.

N/A

0.228DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access3 citations · 3 citing works in its network

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Data availability

Repositories this paper deposited data in (declared in PubMed).

ClinicalTrials.govNCT04105543

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (7 grants)Impact (FWCI 1.55)OA: goldTopics (63)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 91%Citation Network 9%

Base Score Contribution

0.208

From this paper's citation signal

Citation Network Contribution

0.0200

From 2 citing papers with measurable signal

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Top 3 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 3 citers.

Pre- and Rehabilitation of Swallowing in Head and Neck Cancer Patients
Current Otorhinolaryngology Reports20253 citations98 referencesContributes 0.014
Phospholipid-Drug Conjugates in Cancer Therapy: Emerging Paradigms and Future Directions
AAPS PharmSciTech202510 citations255 referencesContributes 0.009
Longitudinal Swallowing and Salivary Changes With CLR 131 and Re‐Irradiation in Recurrent Head and Neck Cancer
Head & Neck20260 citations27 referencesContributes 0.000

Authors (18)

Adam Burr,Randall J. Kimple ORCID,David P. Adam ORCID,Menggang Yu ORCID,Shari M. Piaskowski

Live enrichment

PubMed:39671752 OpenAlex:https://openalex.org/W4405322399

University of Wisconsin Carbone Cancer Center

Grant: P30 CA014520

National Institutes of Health

Grant: 2UL1TR002373-06

University of Wisconsin Institute for Clinical and Translational Research

National Institutes of Health

Grant: 5P30CA014520-18

CANCER CENTER SUPPORT

National Institutes of Health

Grant: 5P50DE026787-02

Head and Neck Cancer SPORE at the University of Wisconsin

NCI NIH HHS

Grant: P50 CA278595

NIDCR NIH HHS

Grant: P50 DE026787

NCATS NIH HHS

Grant: UL1 TR002373

FWCI

1.55

Citation Percentile

0.8%

Citation Trend

2025

2026

goldLicense: cc-by-nc-nd

journalhttps://doi.org/10.1016/j.ebiom.2024.105496

publisherhttps://doi.org/10.1016/j.ebiom.2024.105496

publisherhttps://api.elsevier.com/content/article/PII:S2352396424005322?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2352396424005322?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/39671752

Fields of Study

Head and Neck Cancer StudiesCancer therapeutics and mechanismsEffects of Radiation Exposure03 medical and health sciences0302 clinical medicineHumansMaleFemaleHead and Neck NeoplasmsMiddle AgedAgedNeoplasm Recurrence, LocalAdultIodine RadioisotopesNeoplasm MetastasisTreatment OutcomeTissue DistributionRadiotherapy Dosage

MeSH Terms

Single Photon Emission Computed Tomography Computed TomographyAdultAgedFemaleHead and Neck NeoplasmsHumansIodine RadioisotopesMaleMiddle AgedNeoplasm MetastasisNeoplasm Recurrence, LocalPhospholipid EthersRadiotherapy DosageTissue DistributionTreatment Outcome

Keywords

MedicineHead and neck cancerToxicityHead and neckRadiation therapyExternal beam radiationOncologyOpen labelNuclear medicineInternal medicineSurgeryClinical trialMaleAdultRadiotherapy DosageArticlesMiddle AgedIodine RadioisotopesTreatment OutcomeHead and Neck NeoplasmsHumansFemaleTissue DistributionNeoplasm Recurrence, LocalNeoplasm MetastasisAgedMonte Carlo methodRadiopharmaceuticalRe-irradiationTargeted radionuclide therapy

Sustainable Development Goals

SDG 0: Good health and well-being

Related Papers (1)

Fiji: an open-source platform for biological-image analysis

N/A

1.7DataRank · unranked

Nature Methods(2012)

co-cited

10.1038/nmeth.2019