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Safety and efficacy of MCO-010 optogenetic therapy in patients with Stargardt disease in USA (STARLIGHT): an open-label multi-center Ph2 trial

EClinicalMedicine(2025)10.1016/j.eclinm.2025.103430Source: DataRank Database

Safety and efficacy of MCO-010 optogenetic therapy in patients with Stargardt disease in USA (STARLIGHT): an open-label multi-center Ph2 trial is a research paper published in EClinicalMedicine (2025). On theSindex it has a DataRank of 0. It has been cited 10 times.

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Open Access10 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (19 grants)Impact (FWCI 3.84)OA: goldTopics (23)IDs (PubMed, PMC, OpenAlex)Annotations (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (22)

Vitaliy Zak,Víctor H. González ORCID,Ninel Z. Gregori,Sai H. Chavala ORCID,Subrata Batabyal ORCID

Live enrichment

PubMed:40838197 PMC:PMC12362400 OpenAlex:https://openalex.org/W4413447791

Foundation Fighting Blindness

Grant: TA-GT-0321-0802-COLUTRAP

National Institutes of Health

Grant: R01EY018213

National Institutes of Health

Grant: R24EY027285

National Institutes of Health

Grant: R01EY024698

National Institutes of Health

Grant: R24EY028758

National Institutes of Health

Grant: 5P30EY019007

National Institutes of Health

Grant: U01EY030580

National Institutes of Health

Grant: U01EY034590

National Institutes of Health

Grant: R01EY033770

National Institutes of Health

Grant: 5U01EY034590-02

Identification of the specific risk allele responsible for oxidative stress in ARMS2/HTRA1-related AMD

National Institutes of Health

Grant: 5R01EY024698-10

Gene Editing and Silencing in Phototransduction

National Institutes of Health

Grant: 5R01EY033770-03

Enhancing cone survival in retinitis pigmentosa through cell-specific therapeutic CRISPR editing of a roxadustat target

National Institutes of Health

Grant: 1R24EY027285-01A1

Translational Gene Therapy for CNGB1 Retinitis Pigmentosa

National Institutes of Health

Grant: 2P30EY019007-06A1

Core Facilities for Vision Research

National Institutes of Health

Grant: 5U01EY030580-02

Precision genome surgery in autologous stem cell transplant

National Institutes of Health

Grant: 5R24EY028758-05

Therapeutic gene editing and multimodal imaging in juvenile macular degeneration

National Institutes of Health

Grant: 2R01EY018213-06A1

Defining Barriers to Gene Therapy

Research to Prevent Blindness

U.S. Food and Drug Administration

FWCI

3.84

Citation Percentile

0.9%

Citation Trend

2025

2026

goldLicense: cc-by-nc-nd

journalhttps://doi.org/10.1016/j.eclinm.2025.103430

GOLDhttps://doi.org/10.1016/j.eclinm.2025.103430

publisherhttps://doi.org/10.1016/j.eclinm.2025.103430

publisherhttps://api.elsevier.com/content/article/PII:S2589537025003621?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2589537025003621?httpAccept=text/plain

Fields of Study

Retinal Development and DisordersPhotoreceptor and optogenetics researchRetinal Diseases and TreatmentsMedicine03 medical and health sciences0302 clinical medicine

Keywords

MedicineStarlightStargardt diseaseOpen labelCenter (category theory)OptometryRandomized controlled trialOphthalmologySurgeryAstronomyMacular degenerationOptogeneticsRetinal Degenerative DiseaseVision RestorationStargardt Macular DegenerationMulti-characteristic OpsinArticles