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Inhibitor design to target a unique feature in the folate pocket of Staphylococcus aureus dihydrofolate reductase

European Journal of Medicinal Chemistry(2020)10.1016/j.ejmech.2020.112412Source: DataRank Database

Inhibitor design to target a unique feature in the folate pocket of Staphylococcus aureus dihydrofolate reductase is a research paper published in European Journal of Medicinal Chemistry (2020). On theSindex it has a DataRank of 0. It has been cited 9 times.

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0DataRank · unranked

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Open Access9 citations

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Enrichment:Funding (6 grants)OA: bronzeTopics (18)IDs (PubMed, PMC)Annotations (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (8)

John White ORCID,Baskar Nammalwar,Ian S. Pratt,Leonard M. Thomas,Richard A. Bunce ORCID

Live enrichment

PubMed:32502861 PMC:PMC7932028

National Institute of Allergy and Infectious Diseases

Grant: R01-AI090685

National Institutes of Health

Grant: P20GM103640

National Science Foundation

Grant: 0922269

National Science Foundation

Grant: BIR-9512269

NIAID NIH HHS

Grant: R01 AI090685

Oklahoma State University

bronzeLicense: http://www.elsevier.com/open-access/userlicense/1.0/

BRONZEhttps://www.sciencedirect.com/science/article/am/pii/S0223523420303834

publisherhttps://www.sciencedirect.com/science/article/am/pii/S0223523420303834

publisherhttps://api.elsevier.com/content/article/PII:S0223523420303834?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0223523420303834?httpAccept=text/plain

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7932028

Fields of Study

ChemistryMedicine

MeSH Terms

Staphylococcus aureusTrimethoprimTetrahydrofolate DehydrogenaseEnzyme InhibitorsMicrobial Sensitivity TestsBinding SitesStructure-Activity RelationshipDrug Design

Keywords

Dihydrofolate reductaseAntibacterialEnzyme inhibitionHeck CouplingFolate PathwayStaphylococcal Aureus2,4-DiaminopyrimidineAlkyl Dihydrophthalazines

Inhibitor design to target a unique feature in the folate pocket of Staphylococcus aureus dihydrofolate reductase

FAIR Checklist

Authors (8)

Funding (6 grants)

Open Access

Topics

Annotations (Europe PMC)