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Design, synthesis, and electrophysiological evaluation of NS6740 derivatives: Exploration of the structure-activity relationship for alpha7 nicotinic acetylcholine receptor silent activation

European Journal of Medicinal Chemistry(2020)10.1016/j.ejmech.2020.112669Source: DataRank Database

Design, synthesis, and electrophysiological evaluation of NS6740 derivatives: Exploration of the structure-activity relationship for alpha7 nicotinic acetylcholine receptor silent activation is a research paper published in European Journal of Medicinal Chemistry (2020). On theSindex it has a DataRank of 0. It has been cited 14 times.

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Open Access14 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (3 grants)OA: greenTopics (34)IDs (PubMed, PMC)

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Authors (7)

Nicole A. Horenstein,Clare Stokes ORCID,Marta Quadri ORCID,Marco De Amici ORCID,Roger L. Papke ORCID

Live enrichment

PubMed:32810771 PMC:PMC7590973

NIGMS NIH HHS

Grant: R01 GM057481

National Institutes of Health

Grant: 5R01GM057481-15

Targeting of alpha7 nAChR for therapeutic effects

National Institutes of Health

greenLicense: Elsevier TDM

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7590973

publisherhttps://api.elsevier.com/content/article/PII:S0223523420306413?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0223523420306413?httpAccept=text/plain

repositoryhttp://hdl.handle.net/2434/768482

repositoryhttps://doi.org/10.7270/q2tb1bnj

Fields of Study

0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

AnimalsXenopus laevisHumansFuransLigandsStructure-Activity RelationshipDrug DesignHydrogen BondingAzabicyclo CompoundsElectrophysiological PhenomenaChemistry Techniques, Syntheticalpha7 Nicotinic Acetylcholine Receptor

Keywords

ElectrophysiologyStructure-activity Relationship (Sar)Partial AgonistΑ7 Nicotinic Acetylcholine ReceptorSilent Agonist1,4-Diazabicyclo[3.2.2]nonanealpha7 Nicotinic Acetylcholine ReceptorHydrogen BondingChemistry Techniques, SyntheticLigandsElectrophysiological PhenomenaStructure-Activity RelationshipXenopus laevisa7 nicotinic acetylcholine receptor; Electrophysiology; Silent agonist; Partial agonist; 1,4-Diazabicyclo[3.2.2]nonane; Structure-activity relationship (SAR)Drug DesignAnimalsHumansFuransAzabicyclo Compounds