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From methylene bridged diindole to carbonyl linked benzimidazoleindole: Development of potent and metabolically stable PCSK9 modulators

European Journal of Medicinal Chemistry(2020)10.1016/j.ejmech.2020.112678Source: DataRank Database

From methylene bridged diindole to carbonyl linked benzimidazoleindole: Development of potent and metabolically stable PCSK9 modulators is a research paper published in European Journal of Medicinal Chemistry (2020). On theSindex it has a DataRank of 0. It has been cited 6 times.

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Scored on demand from live citation data

Open Access6 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (4 grants)Impact (FWCI 1.17)OA: greenTopics (46)IDs (PubMed, PMC, OpenAlex)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (8)

Ka Yang ORCID,Gabrielle Winston‐McPherson ORCID,Donnie S. Stapleton ORCID,Mark P. Keller ORCID,Alan Attie ORCID

Live enrichment

PubMed:32823006 PMC:PMC7572704 OpenAlex:https://openalex.org/W3047528703

NIDDK NIH HHS

Grant: R01 DK101573

NIGMS NIH HHS

Grant: R01 GM120357

National Institutes of Health

Grant: 5R01GM120357-02

Targeting Lipid Regulation Pathways by Novel Small Molecules

National Institutes of Health

FWCI

1.17

Citation Percentile

0.8%

Citation Trend

2021

2022

2023

greenLicense: Elsevier TDM

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7572704

publisherhttps://api.elsevier.com/content/article/PII:S0223523420306504?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0223523420306504?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.ejmech.2020.112678

Fields of Study

Lipoproteins and Cardiovascular HealthComputational Drug Discovery MethodsMelanoma and MAPK Pathways0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

Proprotein Convertase 9AnimalsBenzimidazolesDrug StabilityHumansIndolesLiverStructure-Activity RelationshipMiceRats

Keywords

ChemistryIn vivoKexinPCSK9Proprotein convertaseStereochemistryIndole testSubtilisinStructure–activity relationshipLipoproteinIn vitroPharmacologyBiochemistryCholesterolLDL receptorEnzymeIndoleMetabolic StabilityPhenotypic ScreeningFluorine ScanIndolesRatsMiceStructure-Activity RelationshipDrug StabilityLiverAnimalsHumansBenzimidazolesProprotein Convertase 9

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Clean water and sanitation