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Discovery of 4-aminoquinolines as highly selective TGFβR1 inhibitors with an attenuated MAP4K4 profile for potential applications in immuno-oncology

European Journal of Medicinal Chemistry(2021)10.1016/j.ejmech.2021.113763Source: DataRank Database

Discovery of 4-aminoquinolines as highly selective TGFβR1 inhibitors with an attenuated MAP4K4 profile for potential applications in immuno-oncology is a research paper published in European Journal of Medicinal Chemistry (2021). On theSindex it has a DataRank of 0. It has been cited 4 times.

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0DataRank · unranked

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Open Access4 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (3 grants)Impact (FWCI 0.22)OA: greenTopics (29)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (6)

Phuc Tran ORCID,Lingtian Zhang ORCID,Yuet‐Kin Leung ORCID,Hongyu Li ORCID,Brendan Frett ORCID

Live enrichment

PubMed:34419892 OpenAlex:https://openalex.org/W3189689752

National Institutes of Health

Grant: 1R01CA194094

National Institutes of Health

Grant: 1R01CA197178

National Institute of General Medical Sciences

Grant: P20 GM109005

FWCI

0.22

Citation Percentile

0.5%

Citation Trend

2023

2024

2025

greenLicense: https://doi.org/10.15223/policy-004

repositoryhttps://doi.org/10.7270/q2pk0m04

publisherhttps://api.elsevier.com/content/article/PII:S0223523421006127?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0223523421006127?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.ejmech.2021.113763

repositoryhttps://pubmed.ncbi.nlm.nih.gov/34419892

Fields of Study

TGF-β signaling in diseasesNF-κB Signaling PathwaysCell Adhesion Molecules Research

MeSH Terms

Receptor, Transforming Growth Factor-beta Type IAminoquinolinesDose-Response Relationship, DrugHumansStructure-Activity RelationshipMolecular StructureProtein Serine-Threonine KinasesIntracellular Signaling Peptides and ProteinsDrug DiscoveryHEK293 Cells

Keywords

ImmunosuppressionImmune systemPharmacologyCytokineChemistryTransforming growth factorCancer researchTumor microenvironmentMedicineImmunologyInternal medicinekinaseTgfβImmuno-oncology4-AminoquinolinesMap4k4

Sustainable Development Goals

SDG 0: Good health and well-being