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Structure activity relationships of 5-HT2B and 5-HT2C serotonin receptor antagonists: N6, C2 and 5′-Modified (N)-methanocarba-adenosine derivatives

European Journal of Medicinal Chemistry(2023)10.1016/j.ejmech.2023.115691Source: DataRank Database

Structure activity relationships of 5-HT2B and 5-HT2C serotonin receptor antagonists: N6, C2 and 5′-Modified (N)-methanocarba-adenosine derivatives is a research paper published in European Journal of Medicinal Chemistry (2023). On theSindex it has a DataRank of 0. It has been cited 3 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access3 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (4 grants)Impact (FWCI 0.50)OA: greenTopics (37)IDs (PubMed, PMC, OpenAlex)Annotations (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (10)

Maggie M. Calkins ORCID,Marko Ivancich,Hailey A. Bock,Ryan G. Campbell,Sarah A. Lewicki ORCID

Live enrichment

PubMed:37562117 PMC:PMC10529765 OpenAlex:https://openalex.org/W4385399914

National Institute of Diabetes and Digestive and Kidney Diseases

Grant: ZIADK031117

National Institute of Diabetes and Digestive and Kidney Diseases

Grant: R35 GM133421

National Institute of Mental Health

Grant: 3.6

National Institute of Mental Health

Grant: HHSN-271-2008-00025-C

FWCI

0.50

Citation Percentile

0.6%

Citation Trend

2023

2024

2025

greenLicense: http://www.elsevier.com/open-access/userlicense/1.0/

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC10529765/pdf/nihms-1924271.pdf

publisherhttps://api.elsevier.com/content/article/PII:S0223523423006578?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0223523423006578?httpAccept=text/plain

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/10529765

Fields of Study

Adenosine and Purinergic SignalingIon channel regulation and functionNicotinic Acetylcholine Receptors StudyAdenosineReceptor, Serotonin, 5-HT2BReceptors, Purinergic P1SerotoninSerotonin AntagonistsStructure-Activity Relationship

MeSH Terms

AdenosineSerotoninSerotonin AntagonistsStructure-Activity RelationshipReceptors, Purinergic P1Receptor, Serotonin, 5-HT2B

Keywords

ChemistryBicyclic moleculeStereochemistryAdenosineAdenosine receptorAgonistReceptorSerotoninSelectivityAdenosine A1 receptorAntagonist5-HT receptorBiochemistryStructure activity relationshipSerotonin receptorNucleosidesG protein-coupled receptorRadioligand BindingFunctional AntagonismMethanocarbaSerotonin 5-Ht(2b) ReceptorScaffold Repurposing