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Magic shotgun approach to anti-inflammatory pharmacotherapy: Synthesis of novel thienopyrimidine monomers/heterodimer as dual COX-2 and 15-LOX inhibitors endowed with potent antioxidant activity

European Journal of Medicinal Chemistry(2023)10.1016/j.ejmech.2023.115724Source: DataRank Database

Magic shotgun approach to anti-inflammatory pharmacotherapy: Synthesis of novel thienopyrimidine monomers/heterodimer as dual COX-2 and 15-LOX inhibitors endowed with potent antioxidant activity is a research paper published in European Journal of Medicinal Chemistry (2023). On theSindex it has a DataRank of 0. It has been cited 24 times.

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0DataRank · unranked

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Open Access24 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (1 grants)Impact (FWCI 2.75)OA: greenTopics (21)IDs (PubMed, PMC, OpenAlex)Annotations (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (6)

Ahmed S. Abdelkhalek ORCID,Samar Rezq ORCID,Mansour E. Abu Kull,Damián G. Romero ORCID,Hend Kothayer

Live enrichment

PubMed:37611534 PMC:PMC10528942 OpenAlex:https://openalex.org/W4385830751

NIGMS NIH HHS

Grant: P20 GM121334

FWCI

2.75

Citation Percentile

0.9%

Citation Trend

2023

2024

2025

2026

greenLicense: http://www.elsevier.com/open-access/userlicense/1.0/

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC10528942/pdf/nihms-1927518.pdf

publisherhttps://api.elsevier.com/content/article/PII:S0223523423006918?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0223523423006918?httpAccept=text/plain

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/10528942

Fields of Study

Synthesis and biological activityInflammatory mediators and NSAID effectsSynthesis and Biological Evaluation

MeSH Terms

Anti-Inflammatory AgentsAntioxidantsArachidonate 15-LipoxygenasePyrimidinesTumor Necrosis Factor-alphaInterleukin-6Lipoxygenase InhibitorsReactive Oxygen SpeciesCyclooxygenase 2Cyclooxygenase 2 Inhibitors

Keywords

ChemistryStereochemistryPharmacologyAntioxidantInflammationHeterodimerThienopyrimidineDual Cox-2/15-lox Inhibitors

Magic shotgun approach to anti-inflammatory pharmacotherapy: Synthesis of novel thienopyrimidine monomers/heterodimer as dual COX-2 and 15-LOX inhibitors endowed with potent antioxidant activity

FAIR Checklist

Authors (6)

Funding (1 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)