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Discovery and optimization of a novel carboxamide scaffold with selective antimalarial activity

European Journal of Medicinal Chemistry(2025)10.1016/j.ejmech.2025.117572Source: DataRank Database

Discovery and optimization of a novel carboxamide scaffold with selective antimalarial activity is a research paper published in European Journal of Medicinal Chemistry (2025). On theSindex it has a DataRank of 0. It has been cited 5 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access5 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (8 grants)Impact (FWCI 3.42)OA: hybridTopics (46)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (14)

Roger Trombley,Maris Podgurski,Anthony A. Ruberto ORCID,Meng Cui ORCID,Caitlin Cooper ORCID

Live enrichment

PubMed:40199028 OpenAlex:https://openalex.org/W4408978428

National Institute of Allergy and Infectious Diseases Division of Microbiology and Infectious Diseases

Grant: R01AI153290

National Institute of Allergy and Infectious Diseases Division of Microbiology and Infectious Diseases

Grant: R01AI144464

National Institutes of Health, Pakistan

Grant: 1K99AI177948-01A1

State of the ART: Functional genomics of RNA-binding proteins and their role in artemisinin drug resistance in Plasmodium falciparum

Northeastern University

Grant: S10OD032452

National Institutes of Health

Grant: 5R01AI144464-02

Orally Bioavailable 4(1H)-Quinolones with Multi-Stage Antimalarial Activity

National Institutes of Health

Grant: 1S10OD032452-01

600MHz NMR Spectrometer

National Institutes of Health

Grant: 5R01AI153290-02

Lead optimization and target identification of drugs targeting hypnozoites

National Institutes of Health

FWCI

3.42

Citation Percentile

0.9%

Citation Trend

2025

2026

hybridLicense: cc-by

journalhttps://doi.org/10.1016/j.ejmech.2025.117572

publisherhttps://doi.org/10.1016/j.ejmech.2025.117572

publisherhttps://api.elsevier.com/content/article/PII:S022352342500337X?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S022352342500337X?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40199028

Fields of Study

Computational Drug Discovery MethodsMalaria Research and ControlSynthesis and biological activityAntimalarialsPlasmodium falciparumStructure-Activity RelationshipParasitic Sensitivity TestsMolecular StructureDrug DiscoveryHumansDose-Response Relationship, DrugAnimalsPicolinic AcidsTriazoles

MeSH Terms

AnimalsAntimalarialsDose-Response Relationship, DrugHumansPicolinic AcidsPlasmodium falciparumStructure-Activity RelationshipTriazolesMolecular StructureParasitic Sensitivity TestsDrug Discovery

Keywords

ChemistryCarboxamideScaffoldDrug discoveryPharmacologyCombinatorial chemistryStereochemistryBiochemistryBiomedical engineeringPlasmodium falciparumAntimalarialPicolinamideAntimalarialsStructure-Activity RelationshipParasitic Sensitivity TestsMolecular StructureDose-Response Relationship, DrugHumansAnimalsTriazolesPicolinic Acids

Sustainable Development Goals

SDG 0: Good health and well-being