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Investigation into the binding domains of platelet factor 4 unlocks new avenues for the design and synthesis of selective sulfated pseudo-tetrasaccharide aminoglycoside ligands

European Journal of Medicinal Chemistry(2025)10.1016/j.ejmech.2025.117792Source: DataRank Database

Investigation into the binding domains of platelet factor 4 unlocks new avenues for the design and synthesis of selective sulfated pseudo-tetrasaccharide aminoglycoside ligands is a research paper published in European Journal of Medicinal Chemistry (2025). On theSindex it has a DataRank of 0. It has been cited 3 times.

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3 citations

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Enrichment:Funding (4 grants)Impact (FWCI 1.67)OA: closedTopics (48)IDs (PubMed, OpenAlex)SDGs (1)

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Reusable (0/3)

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Authors (4)

Hawau Abdulsalam,Kartikey Singh ORCID,Hien M. Nguyen ORCID,Livia Philip

Live enrichment

PubMed:40424780 OpenAlex:https://openalex.org/W4410558142

National Institutes of Health

Grant: S10OD028488

National Institutes of Health

Grant: R01GM098285

NIH National Institute of General Medical Sciences

Grant: R35 GM149213

Wayne State University

FWCI

1.67

Citation Percentile

0.8%

Citation Trend

2025

2026

closedLicense: http://www.elsevier.com/open-access/userlicense/1.0/

publisherhttps://api.elsevier.com/content/article/PII:S0223523425005574?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0223523425005574?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.ejmech.2025.117792

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40424780

Fields of Study

Proteoglycans and glycosaminoglycans researchPlatelet Disorders and TreatmentsCarbohydrate Chemistry and SynthesisStructure-Activity RelationshipHumansLigandsAminoglycosidesDrug DesignPlatelet Factor 4Molecular StructureBinding SitesSulfatesDose-Response Relationship, DrugOligosaccharidesGlucuronidaseCell SurvivalHeparanase

MeSH Terms

HeparanaseAminoglycosidesBinding SitesCell SurvivalDose-Response Relationship, DrugGlucuronidaseHumansLigandsOligosaccharidesPlatelet Factor 4Structure-Activity RelationshipSulfatesDrug DesignMolecular Structure

Keywords

ChemistryTetrasaccharideStereochemistryAminoglycosideSulfationPlateletChemical synthesisBiochemistryCombinatorial chemistryAntibioticsIn vitroHeparinPlatelet factor 4heparanaseParomomycinHeparan SulfateAnd Neomycin

Sustainable Development Goals

SDG 0: Sustainable cities and communities

Investigation into the binding domains of platelet factor 4 unlocks new avenues for the design and synthesis of selective sulfated pseudo-tetrasaccharide aminoglycoside ligands

FAIR Checklist

Authors (4)

Funding (4 grants)

Impact

Open Access

Topics