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Design, synthesis, evaluation and X-ray structural studies of potent HIV-1 protease inhibitors containing substituted oxaspirocyclic carbamates as the P2 ligands

European Journal of Medicinal Chemistry(2025)10.1016/j.ejmech.2025.117880Source: DataRank Database

Design, synthesis, evaluation and X-ray structural studies of potent HIV-1 protease inhibitors containing substituted oxaspirocyclic carbamates as the P2 ligands is a research paper published in European Journal of Medicinal Chemistry (2025). On theSindex it has a DataRank of 0.

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Linked data & code

CCDC 2446748: Experimental Crystal Structure Determination · Cambridge Crystallographic Data Centre

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (14 grants)OA: greenTopics (20)Linked Datasets (1)DataCite Reuse (1)IDs (PubMed, PMC)Annotations (2)

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Authors (9)

Ryan Shaktah ORCID,Ajay K. Ghosh,Megan Johnson ORCID,Dipendra Bhandari ORCID,Masayuki Amano ORCID

Live enrichment

PubMed:40644923 PMC:PMC12282846

National Institutes of Health

Grant: AI150466

Japan Agency for Medical Research and Development

Grant: JP15fk0410001

Japan Agency for Medical Research and Development

Grant: JP16fk041001

NIAID NIH HHS

Grant: R37 AI150466

NIAID NIH HHS

Grant: R01 AI150466

U.S. Department of Energy

Center for Cancer Research

Basic Energy Sciences

National Cancer Institute

Oak Ridge National Laboratory

Ministry of Education, Culture, Sports, Science and Technology

National Center for Global Health and Medicine

Office of Science

UT-Battelle

greenLicense: http://www.elsevier.com/open-access/userlicense/1.0/

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12282846/

publisherhttps://api.elsevier.com/content/article/PII:S0223523425006452?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0223523425006452?httpAccept=text/plain

MeSH Terms

HumansHIV-1CarbamatesSpiro CompoundsHIV ProteaseHIV Protease InhibitorsLigandsCrystallography, X-RayMolecular StructureStructure-Activity RelationshipDose-Response Relationship, DrugDrug DesignModels, Molecular

Keywords

InhibitorsHIV-1 proteaseX-Ray crystal structureAntiviralDarunavirBackbone BindingOxaspirocyclic

CCDC 2446748: Experimental Crystal Structure Determination

10.5517/ccdc.csd.cc2n41c7Cambridge Crystallographic Data Centre