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Targeting neuroinflammation by activation of the sigma-1 receptor (S1R) and inhibition of butyrylcholinesterase (hBChE) leads to highly potent anti-amnesic compounds in an Alzheimer's disease mouse model

European Journal of Medicinal Chemistry(2025)10.1016/j.ejmech.2025.118486Source: DataRank Database

Targeting neuroinflammation by activation of the sigma-1 receptor (S1R) and inhibition of butyrylcholinesterase (hBChE) leads to highly potent anti-amnesic compounds in an Alzheimer's disease mouse model is a research paper published in European Journal of Medicinal Chemistry (2025). On theSindex it has a DataRank of 0. It has been cited 4 times.

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Scored on demand from live citation data

Open Access4 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (12 grants)Impact (FWCI 1.53)OA: hybridTopics (68)IDs (PubMed, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (12)

Lucie Crouzier ORCID,Tina Gehrig,Alix Flake,E. Schaller,Johann Meunier ORCID

Live enrichment

PubMed:41547241 OpenAlex:https://openalex.org/W4417299548

Radiation Research Foundation

Grant: 5.2.1.1

Radiation Research Foundation

Grant: 0/2/24/I/CFLA/001

Radiation Research Foundation

Grant: 53/OSI/PA

Deutscher Akademischer Austauschdienst

Grant: 57702280

Deutscher Akademischer Austauschdienst

Grant: CA23156

Agence Nationale de la Recherche

Grant: DFG DE1546/12-1

Agence Nationale de la Recherche

Grant: FK03-2020

Agence Nationale de la Recherche

Grant: ANR-22-CE92-0080

Novel sigma-1 pharmacological agents for photopharmacology and neuroprotection

Deutsche Forschungsgemeinschaft

Grant: unidentified

unidentified

Franco-Bavarian Centre for University Cooperation

German Research Foundation

European Cooperation in Science and Technology

FWCI

1.53

Citation Percentile

0.8%

Citation Trend

2026

hybridLicense: cc-by

journalhttps://www.sciencedirect.com/science/article/pii/S0223523425012516/pdf

HYBRIDhttps://www.sciencedirect.com/science/article/pii/S0223523425012516/pdf

publisherhttps://www.sciencedirect.com/science/article/pii/S0223523425012516/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0223523425012516?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0223523425012516?httpAccept=text/plain

Fields of Study

Pharmacological Receptor Mechanisms and EffectsCholinesterase and Neurodegenerative DiseasesNicotinic Acetylcholine Receptors StudyMedicineChemistry03 medical and health sciences0302 clinical medicineAnimalsReceptors, sigmaAlzheimer DiseaseButyrylcholinesteraseMiceSigma-1 ReceptorDisease Models, AnimalHumansCholinesterase InhibitorsStructure-Activity RelationshipDose-Response Relationship, DrugNeuroprotective AgentsNeuroinflammatory DiseasesMolecular StructureAmnesiaMaleAmyloid beta-Peptides

MeSH Terms

Neuroinflammatory DiseasesSigma-1 ReceptorAlzheimer DiseaseAmnesiaAnimalsButyrylcholinesteraseCholinesterase InhibitorsDisease Models, AnimalDose-Response Relationship, DrugHumansMaleStructure-Activity RelationshipMolecular StructureAmyloid beta-PeptidesReceptors, sigmaNeuroprotective AgentsMice

Keywords

ButyrylcholinesteraseNeuroprotectionNeuroinflammationIn vivoIsoindolineReceptorEnzymeBiological activityAlzheimer's diseaseSigma-1 ReceptorMulti-target Directed LigandsMaleMolecular StructureDose-Response Relationship, Drug[SDV] Life Sciences [q-bio]MiceDisease Models, AnimalStructure-Activity RelationshipNeuroprotective AgentsAlzheimer DiseaseNeuroinflammatory DiseasesAnimalsReceptors, sigmaHumansCholinesterase InhibitorsAmnesiaAlzheimer’s disease