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Discovery of an orally bioavailable pyridone-based BRD4 inhibitor with potent antitumor efficacy in colorectal cancer

European Journal of Medicinal Chemistry(2026)10.1016/j.ejmech.2026.118573Source: DataRank Database

Discovery of an orally bioavailable pyridone-based BRD4 inhibitor with potent antitumor efficacy in colorectal cancer is a research paper published in European Journal of Medicinal Chemistry (2026). On theSindex it has a DataRank of 0.104. It has been cited 1 time.

N/A

0.104DataRank · unranked

Scored on demand from live citation data

1 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (4 grants)Impact (FWCI 3.21)OA: closedTopics (54)IDs (PubMed, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (0/2)

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.104

From this paper's citation signal

Citation Network Contribution

Citation network not refreshed for this result

This paper's DataRank is currently driven only by its base citation score. Citation network data was not refreshed for this result.

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Authors (8)

Shuai Zhan,Churu Mao,Ningjing Zhang ORCID,Xiaofeng Zhao ORCID,Yun Huang ORCID

Live enrichment

PubMed:41544579 OpenAlex:https://openalex.org/W7122493668

Zhejiang University

Grant: 2025YQ005

Hainan Provincial Department of Science and Technology

Grant: ZDYF2025SHFZ053

Hainan Provincial Department of Science and Technology

Grant: 820LH034

Sanya Yazhou Bay Science and Technology City

FWCI

3.21

Citation Percentile

0.8%

Citation Trend

2026

closedLicense: https://doi.org/10.15223/policy-004

publisherhttps://api.elsevier.com/content/article/PII:S0223523426000188?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0223523426000188?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.ejmech.2026.118573

repositoryhttps://pubmed.ncbi.nlm.nih.gov/41544579

Fields of Study

Protein Degradation and InhibitorsChromatin Remodeling and CancerClick Chemistry and ApplicationsBromodomain Containing ProteinsHumansAnimalsCell Cycle ProteinsAntineoplastic AgentsColorectal NeoplasmsTranscription FactorsMiceAdministration, OralCell ProliferationStructure-Activity RelationshipDrug DiscoveryPyridonesDrug Screening Assays, AntitumorDose-Response Relationship, DrugMolecular StructureBiological AvailabilityMice, NudeNeoplasms, Experimental

MeSH Terms

Bromodomain Containing ProteinsAdministration, OralAnimalsAntineoplastic AgentsBiological AvailabilityDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMice, NudeNeoplasms, ExperimentalNuclear ProteinsPyridonesStructure-Activity RelationshipTranscription FactorsColorectal NeoplasmsMolecular StructureCell Cycle ProteinsHCT116 CellsCell ProliferationMiceDrug Discovery

Keywords

Colorectal cancerBRD4Virtual screeningSmall moleculeBioavailabilityCancerCell growthStructure–activity relationshipIn Vivo Antitumor ActivityStructure-guided Drug DesignBromodomain-containing Protein 4 (Brd4)

Discovery of an orally bioavailable pyridone-based BRD4 inhibitor with potent antitumor efficacy in colorectal cancer

FAIR Checklist

DataRank Breakdown

Authors (8)

Funding (4 grants)

Impact

Open Access

Topics