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Research progress on the mechanisms of action, pharmacological activities and clinical application of P-glycoprotein inhibitors

European Journal of Pharmacology(2026)10.1016/j.ejphar.2026.178546Source: DataRank Database

Research progress on the mechanisms of action, pharmacological activities and clinical application of P-glycoprotein inhibitors is a research paper published in European Journal of Pharmacology (2026). On theSindex it has a DataRank of 0.215. It has been cited 3 times, with 3 citing works in its 1-hop citation network.

N/A

0.215DataRank · unranked

Scored on demand from live citation data

3 citations · 3 citing works in its network

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DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (3 grants)Impact (FWCI 13.83)OA: closedTopics (35)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (0/2)

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 97%Citation Network 3%

Base Score Contribution

0.208

From this paper's citation signal

Citation Network Contribution

7.19 × 10⁻³

From 1 citing papers with measurable signal

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Top 3 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 3 citers.

Thioxanthone-Mediated Cytoprotection Against Cisplatin Toxicity: Exploring the Potential Involvement of P-Glycoprotein Through Computational and Experimental Approaches
Journal of Xenobiotics20261 citations82 referencesContributes 0.008
Bacterioruberin from Haloferax mediterranei Triggers Cytotoxic and Pro-Oxidant Effects in Different Solid Tumour Models, Effectively Targeting P-gp-Resistant Lung Cancer Cells
International Journal of Molecular Sciences20260 citations75 referencesContributes 0.000
Discovery of novel 4-indolyl triazolo[1,5-a]pyrimidine derivatives as highly potent reversal agents against ABCB1-mediated multidrug resistance
Chinese Chemical Letters20260 citations31 referencesContributes 0.000

Authors (6)

Jianhua Wang ORCID,Yuna Fu,Ruifeng Hao,Qiuyue Xie,Letian Zhang ORCID

Live enrichment

PubMed:41534556 OpenAlex:https://openalex.org/W7123358427

Natural Science Foundation Project of Chongqing

Grant: cstc2018jscx-mszd0280

National Key Scientific Instrument and Equipment Development Projects of China

Grant: 21827812

National Natural Science Foundation of China

FWCI

13.83

Citation Percentile

1.0%

Citation Trend

2026

closedLicense: https://doi.org/10.15223/policy-004

publisherhttps://api.elsevier.com/content/article/PII:S0014299926000282?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0014299926000282?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.ejphar.2026.178546

repositoryhttps://pubmed.ncbi.nlm.nih.gov/41534556

Fields of Study

Drug Transport and Resistance MechanismsNanoparticle-Based Drug DeliveryProtein Interaction Studies and Fluorescence AnalysisMedicineChemistryHumansAnimalsATP Binding Cassette Transporter, Subfamily B, Member 1Drug Resistance, NeoplasmDrug Resistance, MultipleAntineoplastic AgentsNeoplasmsStructure-Activity Relationship

MeSH Terms

AnimalsAntineoplastic AgentsHumansNeoplasmsStructure-Activity RelationshipDrug Resistance, MultipleDrug Resistance, NeoplasmATP Binding Cassette Transporter, Subfamily B, Member 1

Keywords

EffluxChemotherapyMechanism of actionMultiple drug resistanceClinical trialDrugCancer chemotherapyTranslation (biology)Mechanism (biology)Pharmacological activityResearch progressClinical researchmultidrug resistance (MDR)P-glycoprotein (P-gp) Inhibitors

Sustainable Development Goals

SDG 0: Good health and well-being

Research progress on the mechanisms of action, pharmacological activities and clinical application of P-glycoprotein inhibitors

FAIR Checklist

DataRank Breakdown

Top 3 citers driving the network score

Authors (6)

Funding (3 grants)

Impact

Open Access

Topics