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Short-term exposure to a clinical dose of metformin increases skeletal muscle mitochondrial H2O2 emission and production in healthy, older adults: A randomized controlled trial

Experimental Gerontology(2022)10.1016/j.exger.2022.111804Source: DataRank Database

Short-term exposure to a clinical dose of metformin increases skeletal muscle mitochondrial H2O2 emission and production in healthy, older adults: A randomized controlled trial is a research paper published in Experimental Gerontology (2022). On theSindex it has a DataRank of 0.538. It has been cited 13 times, with 13 citing works in its 1-hop citation network.

N/A

0.538DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access13 citations · 13 citing works in its network

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Linked data & code

gen nct

Data availability

Repositories this paper deposited data in (declared in PubMed).

ClinicalTrials.govNCT03107884

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (28 grants)Impact (FWCI 0.94)OA: hybridTopics (43)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 74%Citation Network 26%

Base Score Contribution

0.396

From this paper's citation signal

Citation Network Contribution

0.142

From 10 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 13 citers.

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Diabetes20245 citations45 referencesContributes 0.040
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Metabolism2023183 citations164 referencesContributes 0.032
Human trials exploring anti-aging medicines
Cell Metabolism2024227 citations181 referencesContributes 0.030
Diabetes Pharmacotherapy and its effects on the Skeletal Muscle EnergyMetabolism
Mini-Reviews in Medicinal Chemistry20244 citations105 referencesContributes 0.015
Type 2 Diabetes Mellitus: A Metabolic Model of Accelerated Aging - Multi-Organ Mechanisms and Intervention Approaches
Aging and Disease20258 citations165 referencesContributes 0.013

Authors (14)

Ziad S. Mahmassani ORCID,Jonathan J. Petrocelli ORCID,Naomi M. M. P. de Hart ORCID,Dennis K. Fix ORCID,Patrick J. Ferrara

Live enrichment

PubMed:35405248 PMC:PMC9237837 OpenAlex:https://openalex.org/W4223506797

National Institutes of Health

Grant: R01DK131609

National Institutes of Health

Grant: R44DK116450

National Institutes of Health

Grant: R01DK115824

National Institutes of Health

Grant: F31AG059438

National Institutes of Health

Grant: R01DK122001-04

National Institutes of Health

Grant: IA 52242

University of Utah

Grant: SC-71

University of Utah

Grant: Pax7

National Center for Research Resources

Grant: 1S10OD021505-01

National Center for Research Resources

Grant: 1S10OD016232-01

National Center for Research Resources

Grant: 1S10OD018210-01A1

National Center for Advancing Translational Sciences

Grant: UL1TR002538

American Diabetes Association

Grant: 1-19-ICTS-107

American Diabetes Association

Grant: R01AG050781

NIDDK NIH HHS

Grant: R01 DK127979

NIDDK NIH HHS

Grant: R01 DK107397

NIH HHS

Grant: S10 OD021505

NIA NIH HHS

Grant: F99 AG073493

NIDDK NIH HHS

Grant: P30 DK020579

NIDDK NIH HHS

Grant: R01 DK122001

NIDDK NIH HHS

Grant: R01 DK130296

NHLBI NIH HHS

Grant: R01 HL142603

NIH HHS

Grant: S10 OD018210

NIA NIH HHS

Grant: R01 AG074535

NIGMS NIH HHS

Grant: R01 GM144613

NIH HHS

Grant: S10 OD016232

Indiana Clinical and Translational Sciences Institute

Eunice Kennedy Shriver National Institute of Child Health and Human Development

FWCI

0.94

Citation Percentile

0.7%

Citation Trend

2023

2024

2025

2026

hybridLicense: cc-by-nc-nd

journalhttps://www.sciencedirect.com/science/article/pii/S0531556522001127/pdf

publisherhttps://www.sciencedirect.com/science/article/pii/S0531556522001127/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0531556522001127?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0531556522001127?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.exger.2022.111804

Fields of Study

Metabolism, Diabetes, and CancerAdipose Tissue and MetabolismNutrition and Health in AgingAgedGlucoseHumansHydrogen PeroxideMetforminMitochondriaMitochondria, MuscleMuscle, Skeletal

MeSH Terms

AgedGlucoseHumansHydrogen PeroxideMetforminMitochondriaMitochondria, MuscleMuscle, Skeletal

Keywords

MetforminRespirometryBioenergeticsInternal medicineSkeletal muscleMitochondrial ROSMitochondrionType 2 diabetesDiabetes mellitusPlaceboEndocrinologyRandomized controlled trialMedicineBiologyOxidative stressPathologyBiochemistryMitochondriaAgingMetabolismFree radicalsmuscle stem cellsInsulin SensitizersComplex I Respiration

Sustainable Development Goals

SDG 0: Good health and well-being