Evolutionary conserved motifs constrain the RNA structure organization of picornavirus IRES is a research paper published in FEBS Letters (2013). On theSindex it has a DataRank of 0.711. It has been cited 20 times, with 12 citing works in its 1-hop citation network.
Picornavirus RNAs initiate translation using a 5′ end‐independent mechanism based on internal ribosome entry site (IRES) elements. Despite performing similar functions, IRES elements present in genetically distant RNAs differ in primary sequence, RNA secondary structure and trans‐acting factors requirement. The lack of conserved features amongst IRESs represents obstacles for the understanding of the internal initiation process. RNA structure is tightly linked to picornavirus IRES activity, consistent with the conservation of RNA motifs. This study extends the functional relevance of evolutionary conserved motifs of foot‐and‐mouth disease virus (FMDV) IRES. SHAPE structural analysis of mutant IRESs revealed local changes in RNA flexibility indicating the existence of an interactive structure constrained by lateral bulges that maintain the RNA conformation necessary for IRES‐mediated translation.
FAIR checklist signals are shown for context only and do not affect DataRank scoring.
Base Score Contribution
0.457
From this paper's citation signal
Citation Network Contribution
0.254
From 9 citing papers with measurable signal
Ranked by citation count — the same ordering the engine uses when summing log1p(Cq) over citers.
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 64% comes from its base citations and 36% from the citation network (9 citing papers contributed measurable signal).
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.
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