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CD47 Ligation Repositions the Inhibitory Receptor SIRPA to Suppress Integrin Activation and Phagocytosis

Immunity(2020)10.1016/j.immuni.2020.07.008Source: DataRank Database

CD47 Ligation Repositions the Inhibitory Receptor SIRPA to Suppress Integrin Activation and Phagocytosis is a research paper published in Immunity (2020). On theSindex it has a DataRank of 6.7. It has been cited 248 times, with 200 citing works in its 1-hop citation network.

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6.7DataRank · unranked

Scored on demand from live citation data

Open Access248 citations · 200 citing works in its network

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (5 grants)Impact (FWCI 8.38)OA: greenTopics (57)Linked Datasets (16)DataCite Reuse (16)IDs (PubMed, PMC, OpenAlex)Annotations (3)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

DataCite relations
Linked datasets

Reusable (0/3)

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DataRank Breakdown

Base Score 12%Citation Network 88%

Base Score Contribution

0.828

From this paper's citation signal

Citation Network Contribution

5.8

From 182 citing papers with measurable signal

Learn more about DataRank methodology →

Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 200 citers.

A siRNA-Assisted Assembly Strategy to Simultaneously Suppress “Self” and Upregulate “Eat-Me” Signals for Nanoenabled Chemo-Immunotherapy
ACS Nano202186 citations32 referencesContributes 0.140
Kindlin3-Dependent CD11b/CD18-Integrin Activation Is Required for Potentiation of Neutrophil Cytotoxicity by CD47–SIRPα Checkpoint Disruption
Cancer Immunology Research202046 citations32 referencesContributes 0.120
An in-situ peptide-antibody self-assembly to block CD47 and CD24 signaling enhances macrophage-mediated phagocytosis and anti-tumor immune responses
Nature Communications202464 citations38 referencesContributes 0.110
CD47-SIRPα Blockade Sensitizes Head and Neck Squamous Cell Carcinoma to Cetuximab by Enhancing Macrophage Adhesion to Cancer Cells
Cancer Research202424 citations30 referencesContributes 0.107
Reactive oxygen species-responsive and Raman-traceable hydrogel combining photodynamic and immune therapy for postsurgical cancer treatment
Nature Communications2022158 citations49 referencesContributes 0.103

Authors (3)

Nadja Kern ORCID,Ronald D. Vale ORCID,Meghan A. Morrissey ORCID

Live enrichment

PubMed:32768386 PMC:PMC7453839 OpenAlex:https://openalex.org/W3048347902

National Institutes of Health

Grant: F32GM120990

NIGMS NIH HHS

Grant: T32 GM008284

National Institute of General Medical Sciences

Howard Hughes Medical Institute

FWCI

8.38

Citation Percentile

1.0%

Citation Trend

2020

2021

2022

2023

2024

2025

2026

greenLicense: http://www.elsevier.com/open-access/userlicense/1.0/

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7453839

publisherhttps://api.elsevier.com/content/article/PII:S1074761320303150?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1074761320303150?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.immuni.2020.07.008

Fields of Study

Phagocytosis and Immune RegulationErythrocyte Function and PathophysiologyImmune cells in cancerAnimalsCD47 AntigenCalreticulinCell LineComplement System ProteinsHEK293 CellsHumansImmunoglobulin GIntegrinsMacrophage ActivationMacrophagesMiceMice, Inbred C57BLPhagocytosisPhosphatidylserinesRAW 264.7 CellsReceptors, ImmunologicSignal Transduction

MeSH Terms

RAW 264.7 CellsAnimalsCell LineComplement System ProteinsHumansImmunoglobulin GMacrophage ActivationMacrophagesMice, Inbred C57BLPhagocytosisPhosphatidylserinesReceptors, ImmunologicSignal TransductionIntegrinsCalreticulinMiceCD47 AntigenHEK293 Cells

Keywords

CD47PhagocytosisIntegrinBiologyLigationReceptorImmunologyCell biologyCancer researchMolecular biologyBiochemistryMacrophageImmunotherapyimmunological synapseFc receptorEngulfmentCheckpoint BlockadeSirpa

Sustainable Development Goals

SDG 0: Good health and well-being

Additional file 1 of Characteristics, prognostic determinants of monocytes, macrophages and T cells in acute coronary syndrome: protocol for a multicenter, prospective cohort study

10.6084/m9.figshare.22721366.v1figshare

Additional file 1 of Characteristics, prognostic determinants of monocytes, macrophages and T cells in acute coronary syndrome: protocol for a multicenter, prospective cohort study

10.6084/m9.figshare.22721366figshare

Additional file 1 of Targeting HDAC6 improves anti-CD47 immunotherapy

10.6084/m9.figshare.25303067.v1figshare

Additional file 1 of Targeting HDAC6 improves anti-CD47 immunotherapy

10.6084/m9.figshare.25303067figshare

Additional file 1 of BCMA/CD47-directed universal CAR-T cells exhibit excellent antitumor activity in multiple myeloma

10.6084/m9.figshare.25893743.v1figshare

Additional file 1 of BCMA/CD47-directed universal CAR-T cells exhibit excellent antitumor activity in multiple myeloma

10.6084/m9.figshare.25893743figshare

Additional file 6 of BCMA/CD47-directed universal CAR-T cells exhibit excellent antitumor activity in multiple myeloma

10.6084/m9.figshare.26724467.v1figshare

Additional file 6 of BCMA/CD47-directed universal CAR-T cells exhibit excellent antitumor activity in multiple myeloma

10.6084/m9.figshare.26724467figshare

Additional file 2 of BCMA/CD47-directed universal CAR-T cells exhibit excellent antitumor activity in multiple myeloma

10.6084/m9.figshare.25893864figshare

Additional file 4 of BCMA/CD47-directed universal CAR-T cells exhibit excellent antitumor activity in multiple myeloma

10.6084/m9.figshare.26724455figshare

Additional file 3 of BCMA/CD47-directed universal CAR-T cells exhibit excellent antitumor activity in multiple myeloma

10.6084/m9.figshare.26724449figshare

Additional file 2 of BCMA/CD47-directed universal CAR-T cells exhibit excellent antitumor activity in multiple myeloma

10.6084/m9.figshare.25893864.v1figshare

Additional file 5 of BCMA/CD47-directed universal CAR-T cells exhibit excellent antitumor activity in multiple myeloma

10.6084/m9.figshare.26724461figshare

Additional file 3 of BCMA/CD47-directed universal CAR-T cells exhibit excellent antitumor activity in multiple myeloma

10.6084/m9.figshare.26724449.v1figshare

Additional file 4 of BCMA/CD47-directed universal CAR-T cells exhibit excellent antitumor activity in multiple myeloma

10.6084/m9.figshare.26724455.v1figshare

Additional file 5 of BCMA/CD47-directed universal CAR-T cells exhibit excellent antitumor activity in multiple myeloma

10.6084/m9.figshare.26724461.v1figshare

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CD47 Ligation Repositions the Inhibitory Receptor SIRPA to Suppress Integrin Activation and Phagocytosis

FAIR Checklist

DataRank Breakdown

Top 5 citers driving the network score

Authors (3)

Funding (5 grants)

Impact

Open Access

Topics

Linked Datasets (16)

Annotations (Europe PMC)

Related Papers (10)