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Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations

Immunity(2021)10.1016/j.immuni.2021.07.008Source: DataRank Database

Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations is a research paper published in Immunity (2021). On theSindex it has a DataRank of 0.863. It has been cited 314 times.

N/A

0.863DataRank · unranked

Scored on demand from live citation data

Open Access314 citations

Cite:

Linked data & code

cellosaurus gen pdb doi

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (36 grants)Impact (FWCI 17.13)OA: bronzeTopics (85)IDs (PubMed, PMC, OpenAlex)Annotations (4)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.863

From this paper's citation signal

Citation Network Contribution

0

Citation network not refreshed for this result

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Authors (28)

Yiska Weisblum ORCID,Christopher O. Barnes ORCID,Fabian Schmidt ORCID,Dennis Schaefer-Babajew ORCID,Zijun Wang ORCID

Live enrichment

PubMed:34331873 PMC:PMC8323339 OpenAlex:https://openalex.org/W3190206472

National Science Foundation

Grant: GRFP DGE-1745301

Basic Energy Sciences

Grant: DE-AC02-c76SF00515

NIGMS

Grant: P41GM103393

Rockefeller University

Grant: 63/021,387

National Center for Advancing Translational Sciences

Grant: UL1 TR001866

National Institute of Allergy and Infectious Diseases

Grant: 2U19AI111825

National Institute of Allergy and Infectious Diseases

Grant: R01AI78788

National Institute of Allergy and Infectious Diseases

Grant: P01-AI138938-S1

National Institute of Allergy and Infectious Diseases

Grant: K99 AI153465

National Institute of Allergy and Infectious Diseases

Grant: R37-AI64003

National Institute of Allergy and Infectious Diseases

Grant: HIV-1-pseudotypes

NIAID NIH HHS

Grant: U19 AI111825

NIAID NIH HHS

Grant: F30 AI157898

NIAID NIH HHS

Grant: R37 AI064003

NIAID NIH HHS

Grant: P01 AI138938

NIAID NIH HHS

Grant: R01 AI078788

National Institutes of Health

Grant: 5UL1TR001866-07

Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success

National Institutes of Health

Grant: 5U19AI111825-02

Modulation of Human Dendritic Cell Development by Adjuvants and Vaccines

National Institutes of Health

Grant: 1P01AI138938-01

Epitope-focused vaccine strategies against Zika virus

National Institutes of Health

Grant: 2R01AI078788-12A1

Overcoming Host Restriction Factors to Develop Better Animal Models for HIV/AIDS

National Institutes of Health

Grant: 8P41GM103393-33

A Synchroton Radiation Structural Biology Resource

National Institutes of Health

Grant: 5R37AI064003-10

Discovery and Mechanism of Antiretroviral Factors

National Institutes of Health

Grant: 1K99AI153465-01

Immunization strategies to elicit broadly neutralizing antibodies against HCV

National Science Foundation

Grant: 1745301

Graduate Research Fellowship Program (GRFP)

Arnold and Mabel Beckman Foundation

Gordon and Betty Moore Foundation

NSF

Caltech

Department of Energy

Burroughs Wellcome Fund

George Mason University

Howard Hughes Medical Institute

Office of Science

Beckman Institute, California Institute of Technology

Biological and Environmental Research

National Institutes of Health

FWCI

17.13

Citation Percentile

1.0%

Citation Trend

2021

2022

2023

2024

2025

2026

bronzeLicense: CC BY NC ND

journalhttp://www.cell.com/article/S1074761321002946/pdf

publisherhttp://www.cell.com/article/S1074761321002946/pdf

publisherhttps://api.elsevier.com/content/article/PII:S1074761321002946?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1074761321002946?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.immuni.2021.07.008

Fields of Study

SARS-CoV-2 and COVID-19 ResearchViral gastroenteritis research and epidemiologyCRISPR and Genetic Engineering0301 basic medicine03 medical and health sciencesAntibodies, NeutralizingAntibodies, ViralAntibody AffinityAntigens, ViralCOVID-19EpitopesHost-Pathogen InteractionsHumansModels, MolecularMutationNeutralization TestsProtein BindingProtein ConformationSARS-CoV-2Spike Glycoprotein, CoronavirusStructure-Activity RelationshipVirulence

MeSH Terms

COVID-19SARS-CoV-2Antibodies, ViralAntibody AffinityEpitopesAntigens, ViralHumansModels, MolecularMutationNeutralization TestsProtein BindingProtein ConformationStructure-Activity RelationshipVirulenceHost-Pathogen InteractionsAntibodies, NeutralizingSpike Glycoprotein, Coronavirus

Keywords

BiologyNeutralizationAntibodyAffinity maturationVirologyPotencyAntigenHeterologousGerminal centerNeutralizing antibodyImmunologyCoronavirusGeneticsCoronavirus disease 2019 (COVID-19)B cellGeneIn vitroDiseaseInfectious disease (medical specialty)AntibodiesSars-cov-2Models, Molecular570Protein ConformationAntibody Affinity610Antibodies, ViralMicrobiologyArticleEpitopesStructure-Activity RelationshipNeutralization TestsHumansAmino AcidsAntigens, ViralVirulenceand ProteinsCOVID-19Antibodies, NeutralizingImmunology of Infectious DiseaseVirus DiseasesHost-Pathogen InteractionsMutationSpike Glycoprotein, CoronavirusPeptidesProtein Binding

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

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