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Medulloblastoma-associated mutations in the DEAD-box RNA helicase DDX3X/DED1 cause specific defects in translation

Journal of Biological Chemistry(2021)10.1016/j.jbc.2021.100296Source: DataRank Database

Medulloblastoma-associated mutations in the DEAD-box RNA helicase DDX3X/DED1 cause specific defects in translation is a research paper published in Journal of Biological Chemistry (2021). On theSindex it has a DataRank of 0.716. It has been cited 21 times, with 16 citing works in its 1-hop citation network.

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0.716DataRank · unranked

Scored on demand from live citation data

Open Access21 citations · 16 citing works in its network

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (6 grants)OA: goldTopics (73)IDs (PubMed, PMC)Annotations (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 65%Citation Network 35%

Base Score Contribution

0.464

From this paper's citation signal

Citation Network Contribution

0.253

From 12 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 16 citers.

The RNA Helicase Ded1 Regulates Translation and Granule Formation during Multiple Phases of Cellular Stress Responses
Molecular and Cellular Biology202121 citations50 referencesContributes 0.062
RNA helicases DDX3X and DDX3Y form nanometer-scale RNA-protein clusters that support catalytic activity
Current Biology202416 citations59 referencesContributes 0.048
The human DEAD-box helicase DDX3X as a regulator of mRNA translation
Frontiers in Cell and Developmental Biology202261 citations140 referencesContributes 0.029
DEAD-box ATPases as regulators of biomolecular condensates and membrane-less organelles
Trends in Biochemical Sciences202236 citations131 referencesContributes 0.028
Contribution of the yeast bi-chaperone system in the restoration of the RNA helicase Ded1 and translational activity under severe ethanol stress
Journal of Biological Chemistry20239 citations86 referencesContributes 0.027

Authors (5)

Ashley M. Vergara,Alisha B. Whelan,Paolo Guerra ORCID,Timothy A. Bolger ORCID,Nicolette P. Brown

Live enrichment

PubMed:33460649 PMC:PMC7949108

NIGMS NIH HHS

Grant: R01 GM136827

National Institute of General Medical Sciences

Grant: 1R01-GM136827

Arizona Biomedical Research Commission

Grant: ADHS14-082993

National Institutes of Health

Grant: 1R01GM136827-01

Regulation of the Translational Response to Cellular Stress

American Cancer Society

National Institutes of Health

goldLicense: CC BY

Unpaywallhttps://doi.org/10.1016/j.jbc.2021.100296

Europe_PMChttps://europepmc.org/articles/PMC7949108

Europe_PMChttps://europepmc.org/articles/PMC7949108?pdf=render

http://www.jbc.org/article/S002192582100065X/pdf

https://pubmed.ncbi.nlm.nih.gov/33460649

Fields of Study

0301 basic medicine0303 health sciences03 medical and health sciences5' Untranslated RegionsAdenosine TriphosphatasesAmino Acid SubstitutionCerebellar NeoplasmsConserved SequenceDEAD-box RNA HelicasesGenes, ReporterGreen Fluorescent ProteinsHumansLuminescent ProteinsMedulloblastomaMutagenesis, Site-DirectedMutationPhenotypeProtein BindingProtein BiosynthesisRNARecombinant ProteinsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsRed Fluorescent Protein

MeSH Terms

HumansSaccharomyces cerevisiaeMedulloblastomaCerebellar NeoplasmsSaccharomyces cerevisiae ProteinsLuminescent ProteinsGreen Fluorescent ProteinsRecombinant ProteinsRNA5' Untranslated RegionsAmino Acid SubstitutionMutagenesis, Site-DirectedProtein BiosynthesisConserved SequenceProtein BindingPhenotypeMutationGenes, ReporterAdenosine TriphosphatasesDEAD-box RNA HelicasesRed Fluorescent Protein

Keywords

Saccharomyces cerevisiaeCancerTranslation initiationMedulloblastomaRNA helicaseTranslation RegulationStress GranuleDead-box ProteinStart Site ScanningAdenosine TriphosphatasesSaccharomyces cerevisiae ProteinsGreen Fluorescent ProteinsRecombinant ProteinsDEAD-box RNA HelicasesLuminescent ProteinsPhenotypeAmino Acid SubstitutionGenes, ReporterProtein BiosynthesisMutationMutagenesis, Site-DirectedHumansRNA5' Untranslated RegionsCerebellar NeoplasmsConserved SequenceResearch ArticleProtein Binding