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Defective binding of SPINK1 variants is an uncommon mechanism for impaired trypsin inhibition in chronic pancreatitis

Journal of Biological Chemistry(2021)10.1016/j.jbc.2021.100343Source: DataRank Database

Defective binding of SPINK1 variants is an uncommon mechanism for impaired trypsin inhibition in chronic pancreatitis is a research paper published in Journal of Biological Chemistry (2021). On theSindex it has a DataRank of 0. It has been cited 25 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access25 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (3 grants)Impact (FWCI 4.46)OA: goldTopics (38)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (6)

Vanda Toldi ORCID,Lívia Diána Gazda,Alexandra Demcsák ORCID,József Tőzsér ORCID,Miklós Sahin‐Tóth ORCID

Live enrichment

PubMed:33515547 PMC:PMC7949130 OpenAlex:https://openalex.org/W3124715823

NIDDK NIH HHS

Grant: R01 DK058088

NIDDK NIH HHS

Grant: R01 DK117809

National Institute of Diabetes and Digestive and Kidney Diseases

FWCI

4.46

Citation Percentile

1.0%

Citation Trend

2021

2022

2023

2024

2025

2026

goldLicense: cc-by

journalhttp://www.jbc.org/article/S0021925821001150/pdf

publisherhttp://www.jbc.org/article/S0021925821001150/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0021925821001150?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925821001150?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.jbc.2021.100343

Fields of Study

Pancreatitis Pathology and TreatmentPancreatic and Hepatic Oncology ResearchPediatric Hepatobiliary Diseases and TreatmentsHEK293 CellsHumansModels, MolecularMutation, MissensePancreatitis, ChronicProtein BindingTrypsinTrypsin Inhibitor, Kazal Pancreatic

MeSH Terms

HumansModels, MolecularProtein BindingTrypsinTrypsin Inhibitor, Kazal PancreaticMutation, MissensePancreatitis, ChronicHEK293 Cells

Keywords

PancreatitisTrypsinSerine proteaseTrypsin inhibitorBiologyProtease inhibitor (pharmacology)TrypsinogenPancreasTyrosineBiochemistryProteaseEnzymeChemistryInternal medicineGeneticsMedicineTyrosine SulfationEquilibrium Binding AssayReactive-site Peptide Bond

Sustainable Development Goals

SDG 0: Good health and well-being

Defective binding of SPINK1 variants is an uncommon mechanism for impaired trypsin inhibition in chronic pancreatitis

FAIR Checklist

Authors (6)

Funding (3 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)