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Optimized binding of substituted quinoline ALLINIs within the HIV-1 integrase oligomer

Journal of Biological Chemistry(2021)10.1016/j.jbc.2021.100363Source: DataRank Database

Optimized binding of substituted quinoline ALLINIs within the HIV-1 integrase oligomer is a research paper published in Journal of Biological Chemistry (2021). On theSindex it has a DataRank of 0. It has been cited 13 times.

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Open Access13 citations

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Enrichment:Funding (8 grants)OA: goldTopics (49)IDs (PubMed, PMC)Annotations (1)SDGs (1)

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Authors (6)

Krunal Patel ORCID,Jared D. Hume ORCID,Julie A. Pigza ORCID,Matthew G. Donahue ORCID,Jacques J. Kessl ORCID

Live enrichment

PubMed:33539919 PMC:PMC7949159

NIAID NIH HHS

Grant: R01 AI140985

NIGMS NIH HHS

Grant: P20 GM103476

NIGMS NIH HHS

Grant: R15 GM129751

National Science Foundation

Grant: 1848257

CAREER: Bridging Synthesis and Computational Chemistry to Parameterize Noncovalent Interactions in Asymmetric Catalysis

National Institutes of Health

Grant: 2R01AI140985-05

New Inhibitors Targeting HIV-1 Integrase During Viral Maturation

National Institutes of Health

Grant: 1R15GM129751-01

Asymmetric Synthesis of Bioactive Nitrogen Heterocycles

National Science Foundation

National Institutes of Health

goldLicense: cc-by

GOLDhttp://www.jbc.org/article/S0021925821001356/pdf

publisherhttp://www.jbc.org/article/S0021925821001356/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0021925821001356?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925821001356?httpAccept=text/plain

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7949159

Fields of Study

MedicineChemistry0301 basic medicine03 medical and health sciences0303 health sciences

MeSH Terms

HumansHIV-1QuinolinesHIV IntegraseIntercellular Signaling Peptides and ProteinsHIV Integrase InhibitorsAntiviral AgentsVirus IntegrationVirus ReplicationAllosteric RegulationProtein BindingModels, MolecularProtein MultimerizationHEK293 Cells

Keywords

Drug designHuman immunodeficiency virusOligomerizationIntegraseQuinolineProtein–protein InteractionAntiviral AgentAlliniModels, Molecular570Virus IntegrationBiophysics610HIV IntegraseVirus ReplicationBiochemistryAntiviral Agentsprotein-protein interactionAllosteric RegulationHumansHIV Integrase InhibitorsLife SciencesHEK293 Cellsand Structural BiologyHIV-1QuinolinesIntercellular Signaling Peptides and ProteinsProtein MultimerizationResearch ArticleProtein Binding

Sustainable Development Goals

SDG 3: 3. Good health

Optimized binding of substituted quinoline ALLINIs within the HIV-1 integrase oligomer

FAIR Checklist

Authors (6)

Funding (8 grants)

Open Access

Topics

Annotations (Europe PMC)