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Hsp70 chaperone blocks α-synuclein oligomer formation via a novel engagement mechanism

Journal of Biological Chemistry(2021)10.1016/j.jbc.2021.100613Source: DataRank Database

Hsp70 chaperone blocks α-synuclein oligomer formation via a novel engagement mechanism is a research paper published in Journal of Biological Chemistry (2021). On theSindex it has a DataRank of 0. It has been cited 69 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access69 citations

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Linked data & code

gen refseq uniprot pdb

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (7 grants)Impact (FWCI 3.92)OA: goldTopics (63)IDs (PubMed, PMC, OpenAlex)Annotations (4)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (8)

Amandine Berthet ORCID,Y. Rose Citron,Paraskevi L. Tsiolaki ORCID,Robert F. Stanley ORCID,Jason E. Gestwicki ORCID

Live enrichment

PubMed:33798554 PMC:PMC8102405 OpenAlex:https://openalex.org/W3149639952

NIGMS NIH HHS

Grant: R35 GM118099

NINDS NIH HHS

Grant: R01 NS059690

NINDS NIH HHS

Grant: R21 NS092897

National Institutes of Health

Grant: 1R21NS092897-01

Small-Molecule Pharmacological Chaperones to Prevent Synuclein Transmission

EMBO

Howard Hughes Medical Institute

NINDS

FWCI

3.92

Citation Percentile

1.0%

Citation Trend

2021

2022

2023

2024

2025

2026

goldLicense: cc-by

journalhttp://www.jbc.org/article/S002192582100394X/pdf

publisherhttp://www.jbc.org/article/S002192582100394X/pdf

publisherhttps://api.elsevier.com/content/article/PII:S002192582100394X?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S002192582100394X?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.jbc.2021.100613

Fields of Study

Heat shock proteins researchEndoplasmic Reticulum Stress and DiseaseCalpain Protease Function and Regulation0301 basic medicine03 medical and health sciences0303 health sciences

MeSH Terms

Adenosine TriphosphateBrain NeoplasmsGliomaHumansMutationTumor Cells, CulturedHSP70 Heat-Shock Proteinsalpha-SynucleinProtein Aggregation, Pathological

Keywords

OligomerChaperone (clinical)Hsp70Mechanism (biology)ChemistryBiophysicsCell biologyAlpha-synucleinHeat shock proteinBiochemistryBiologyMedicineParkinson's diseaseProtein foldingChaperoneα-synucleinSynucleinopathyLewy Body Dementia570Biochemistry & Molecular BiologyBiomedical and clinical sciences1.1 Normal biological development and functioning610NeurodegenerativeMedical and Health SciencesProtein Aggregation, PathologicalAdenosine TriphosphateUnderpinning researchPathologicalAcquired Cognitive ImpairmentTumor Cells, Cultured2.1 Biological and endogenous factorsHumansHSP70 Heat-Shock ProteinsAetiologyCulturedBrain NeoplasmsGliomaBiological SciencesProtein AggregationBrain DisordersTumor CellsChemical sciencesNeurologicalMutationDementiaBiochemistry and Cell BiologyResearch Article