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TGF-β/activin signaling promotes CDK7 inhibitor resistance in triple-negative breast cancer cells through upregulation of multidrug transporters

Journal of Biological Chemistry(2021)10.1016/j.jbc.2021.101162Source: DataRank Database

TGF-β/activin signaling promotes CDK7 inhibitor resistance in triple-negative breast cancer cells through upregulation of multidrug transporters is a research paper published in Journal of Biological Chemistry (2021). On theSindex it has a DataRank of 0.416. It has been cited 15 times.

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0.416DataRank · unranked

Scored on demand from live citation data

Open Access15 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (13 grants)Impact (FWCI 0.89)OA: goldTopics (76)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.416

From this paper's citation signal

Citation Network Contribution

Citation network not refreshed for this result

This paper's DataRank is currently driven only by its base citation score. Citation network data was not refreshed for this result.

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Authors (7)

Benjamin L. Bryson ORCID,Eduardo Williams-Medina,Jessica R. Bobbitt ORCID,Darcie D. Seachrist ORCID,Lindsey J. Anstine ORCID

Live enrichment

PubMed:34481843 PMC:PMC8498470 OpenAlex:https://openalex.org/W3196533448

National Institutes of Health

Grant: T32GM007250

National Institutes of Health

Grant: T32GM008803

National Institutes of Health

Grant: T32GM135081

US Department of Defense

Grant: W81XWH-18-1-0455

National Cancer Institute

Grant: F31CA224809

National Cancer Institute

Grant: R01CA206505

Case Comprehensive Cancer Center, Case Western Reserve University

Grant: P30CA043703

National Institutes of Health

Grant: 5T32GM008803-17

Pre-doctoral Training Program in Molecular Therapeutics

National Institutes of Health

Grant: 5T32GM007250-46

Medical Scientist Training Program

National Institutes of Health

Grant: 3P30CA043703-20S1

Case Comprehensive Cancer Center Support Grant

National Institutes of Health

Grant: 1R01CA206505-01

Targeting BET proteins in Triple Negative Breast Cancer

National Institutes of Health

Grant: 5T32GM135081-03

Functional Genomics Training Program (FGTP)

National Institutes of Health

Grant: 5F31CA224809-03

Defining the Super-Enhancer Landscape in Triple Negative Breast Cancer Subtypes

FWCI

0.89

Citation Percentile

0.8%

Citation Trend

2022

2023

2024

2025

2026

goldLicense: cc-by-nc-nd

journalhttp://www.jbc.org/article/S0021925821009649/pdf

publisherhttp://www.jbc.org/article/S0021925821009649/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0021925821009649?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925821009649?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.jbc.2021.101162

Fields of Study

Pancreatic and Hepatic Oncology ResearchGenetic factors in colorectal cancerTGF-β signaling in diseases0301 basic medicine0303 health sciences03 medical and health sciencesATP Binding Cassette Transporter, Subfamily G, Member 2Cell Line, TumorCyclin-Dependent KinasesDrug Resistance, NeoplasmFemaleGene Expression Regulation, NeoplasticHumansInhibin-beta SubunitsNeoplasm ProteinsProtein Kinase InhibitorsSignal TransductionTransforming Growth Factor betaTriple Negative Breast NeoplasmsUp-RegulationCyclin-Dependent Kinase-Activating Kinase

MeSH Terms

ATP Binding Cassette Transporter, Subfamily G, Member 2Cyclin-Dependent Kinase-Activating KinaseFemaleHumansNeoplasm ProteinsSignal TransductionUp-RegulationGene Expression Regulation, NeoplasticTransforming Growth Factor betaCyclin-Dependent KinasesDrug Resistance, NeoplasmInhibin-beta SubunitsCell Line, TumorProtein Kinase InhibitorsTriple Negative Breast Neoplasms

Keywords

Downregulation and upregulationAbcg2Cancer researchGene silencingBiologyCyclin-dependent kinase 7Signal transductionSmall interfering RNACell biologyProtein kinase BCell cultureATP-binding cassette transporterTransporterGeneticsMAP kinase kinase kinaseTransfectionGeneActivinTGF-βTriple-negative Breast CancerMultidrug TransportersTnbcCdk7Thz1Sy-1365Triple Negative Breast NeoplasmsCyclin-Dependent KinasesNeoplasm ProteinsUp-RegulationGene Expression Regulation, NeoplasticDrug Resistance, NeoplasmTransforming Growth Factor betaCell Line, TumorATP Binding Cassette Transporter, Subfamily G, Member 2HumansFemaleProtein Kinase InhibitorsCyclin-Dependent Kinase-Activating KinaseResearch ArticleInhibin-beta Subunits

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

TGF-β/activin signaling promotes CDK7 inhibitor resistance in triple-negative breast cancer cells through upregulation of multidrug transporters

FAIR Checklist

DataRank Breakdown

Authors (7)

Funding (13 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)