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Tryptophan (W) at position 37 of murine IL-12/IL-23 p40 is mandatory for binding to IL-12Rβ1 and subsequent signal transduction

Journal of Biological Chemistry(2021)10.1016/j.jbc.2021.101295Source: DataRank Database

Tryptophan (W) at position 37 of murine IL-12/IL-23 p40 is mandatory for binding to IL-12Rβ1 and subsequent signal transduction is a research paper published in Journal of Biological Chemistry (2021). On theSindex it has a DataRank of 0. It has been cited 11 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access11 citations

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Linked data & code

uniprot pdb

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (1 grants)Impact (FWCI 0.59)OA: goldTopics (35)IDs (PubMed, PMC, OpenAlex)Annotations (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (11)

Yvonne Arlt,Jens M. Moll ORCID,Meryem Ouzin ORCID,Hendrik T. Weitz ORCID,Lothar Gremer ORCID

Live enrichment

PubMed:34637790 PMC:PMC8571081 OpenAlex:https://openalex.org/W3206915405

NIGMS NIH HHS

Grant: P41 GM103311

FWCI

0.59

Citation Percentile

0.6%

Citation Trend

2022

2023

2024

2025

2026

goldLicense: cc-by

journalhttp://www.jbc.org/article/S0021925821011017/pdf

publisherhttp://www.jbc.org/article/S0021925821011017/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0021925821011017?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925821011017?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.jbc.2021.101295

Fields of Study

Psoriasis: Treatment and PathogenesisDermatology and Skin DiseasesCytokine Signaling Pathways and Interactions

MeSH Terms

AnimalsCricetulusHumansProtein BindingTryptophanSignal TransductionCHO CellsMiceReceptors, Interleukin-12Interleukin-12 Subunit p40Protein MultimerizationHEK293 Cells

Keywords

Signal transductionReceptorAmino acidCytokineBinding siteBiologyChemistryCell biologyMolecular biologyBiochemistryImmunologyIL-12ERKIL-23StatProtein–protein InteractionIl-23rIl-12rβ2Il-12rβ1Site 1-2-3 Paradigm