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Progesterone receptor membrane component 1 (PGRMC1) binds and stabilizes cytochromes P450 through a heme-independent mechanism

Journal of Biological Chemistry(2021)10.1016/j.jbc.2021.101316Source: DataRank Database

Progesterone receptor membrane component 1 (PGRMC1) binds and stabilizes cytochromes P450 through a heme-independent mechanism is a research paper published in Journal of Biological Chemistry (2021). On theSindex it has a DataRank of 0. It has been cited 37 times.

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Open Access37 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (23 grants)Impact (FWCI 5.25)OA: goldTopics (47)IDs (PubMed, PMC, OpenAlex)Annotations (6)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (11)

Debaditya Mukhopadhyay ORCID,Stephanie L. Myers ORCID,Eric P. Mosher ORCID,Rita T. Brookheart ORCID,Kai Kammers ORCID

Live enrichment

PubMed:34678314 PMC:PMC8591507 OpenAlex:https://openalex.org/W3206212320

NIGMS NIH HHS

Grant: T32 GM135083

NIH HHS

Grant: T32 OD011089

NIGMS NIH HHS

Grant: T32 GM007445

NHLBI NIH HHS

Grant: F31 HL131185

NIAID NIH HHS

Grant: R01 AI128781

NHLBI NIH HHS

Grant: F32 HL106971

NIGMS NIH HHS

Grant: R01 GM126088

NHLBI NIH HHS

Grant: R01 HL077588

NHLBI NIH HHS

Grant: R21 HL094774

National Institutes of Health

Grant: 1F32HL106971-01

The role of PGRMC1 in hepatic cholesterol homeostasis

National Institutes of Health

Grant: 5T32GM135083-04

Pharmacology and Molecular Sciences Training Program

National Institutes of Health

Grant: 5R01GM126088-04

Lipid Regulation of Hypoxia-inducible Factors

National Institutes of Health

Grant: 1R21HL094774-01A1

Functional studies of PGRMC1 in cholesterol homeostasis

National Institutes of Health

Grant: 2T32OD011089-39

Training Veterinarians for Careers in Biomedical Research

National Institutes of Health

Grant: 5T32GM007445-33

Biochemistry, Cellular and Molecular Biology Program

National Institutes of Health

Grant: 5R01HL077588-18

Regulation of Cellular Cholesterol Homeostasis

National Institutes of Health

Grant: 5R01AI128781-03

Developmental Pharmacology of Antiretroviral Metabolism in Mucosal Tissues

National Institutes of Health

Grant: 1F31HL131185-01

Pgrmc1 as a regulator of cytochrome P450 enzymes in cholesterol metabolism

National Institute of General Medical Sciences

National Heart Lung and Blood Institute

American Heart Association Inc

National Institute of Allergy and Infectious Diseases

National Institutes of Health Office of the Director

FWCI

5.25

Citation Percentile

1.0%

Citation Trend

2021

2022

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://doi.org/10.1016/j.jbc.2021.101316

publisherhttps://doi.org/10.1016/j.jbc.2021.101316

publisherhttps://api.elsevier.com/content/article/PII:S0021925821011224?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925821011224?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/34678314

Fields of Study

Pharmacogenetics and Drug MetabolismDrug Transport and Resistance MechanismsEstrogen and related hormone effects0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

AnimalsCytochrome P-450 Enzyme SystemEnzyme StabilityHeLa CellsHemeHumansMembrane ProteinsReceptors, ProgesteroneMice, KnockoutAmino Acid SubstitutionMutation, MissenseMiceHela Cells

Keywords

HemeCytochrome P450HemeproteinBiochemistryBiologyMutantPlasma protein bindingCytochromeChemistryEnzymeCell biologyGeneProtein turnoverDrug metabolismLiver MetabolismEnzyme DegradationMice, KnockoutMutation, MissenseMembrane ProteinsMiceAmino Acid SubstitutionCytochrome P-450 Enzyme SystemEnzyme StabilityAnimalsHumansReceptors, ProgesteroneResearch ArticleHeLa Cells

Progesterone receptor membrane component 1 (PGRMC1) binds and stabilizes cytochromes P450 through a heme-independent mechanism

FAIR Checklist

Authors (11)

Funding (23 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)