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Oxidation of specific tryptophan residues inhibits high-affinity binding of cocaine and its metabolites to a humanized anticocaine mAb

Journal of Biological Chemistry(2022)10.1016/j.jbc.2022.101689Source: DataRank Database

Oxidation of specific tryptophan residues inhibits high-affinity binding of cocaine and its metabolites to a humanized anticocaine mAb is a research paper published in Journal of Biological Chemistry (2022). On theSindex it has a DataRank of 0. It has been cited 5 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access5 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (4 grants)Impact (FWCI 0.59)OA: goldTopics (37)IDs (PubMed, OpenAlex)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (3)

Andrew B. Norman ORCID,Kenneth D. Greis ORCID,Terence L. Kirley ORCID

Live enrichment

PubMed:35143837 OpenAlex:https://openalex.org/W4210283912

National Institute on Drug Abuse

Grant: U01DA050330

National Institutes of Health

Grant: 1U01DA050330-01

IND-Enabling Pre-Clinical Studies to Accelerate the Clinical Development of a Humanized Anti-Cocaine Monoclonal Antibody

National Institutes of Health

Grant: 1S10OD026717-01

An Orbitrap Mass Spectrometry System for the University of Cincinnati Proteomics Laboratory

NIH HHS

Grant: S10 OD026717

FWCI

0.59

Citation Percentile

0.6%

Citation Trend

2022

2023

2025

2026

goldLicense: cc-by-nc-nd

journalhttps://doi.org/10.1016/j.jbc.2022.101689

publisherhttps://doi.org/10.1016/j.jbc.2022.101689

publisherhttps://api.elsevier.com/content/article/PII:S0021925822001296?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925822001296?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/35143837

Fields of Study

Forensic Toxicology and Drug AnalysisNeurotransmitter Receptor Influence on BehaviorTryptophan and brain disorders0301 basic medicine0303 health sciences03 medical and health sciencesAntibodies, Monoclonal, HumanizedCocaineImmunoglobulin Fab FragmentsOxidation-ReductionTryptophan

MeSH Terms

CocaineImmunoglobulin Fab FragmentsOxidation-ReductionTryptophanAntibodies, Monoclonal, Humanized

Keywords

BenzoylecgonineChemistryTryptophanMonoclonal antibodyLigand (biochemistry)Binding siteBiochemistryPharmacologyMetaboliteReceptorAmino acidAntibodyBiologyImmunoglobulin Fab FragmentsCocaineAntibodies, Monoclonal, HumanizedOxidation-ReductionResearch Articleaddiction therapyligand affinityoxidation

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being