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Structural and functional insights into the inhibition of human voltage-gated sodium channels by μ-conotoxin KIIIA disulfide isomers

Journal of Biological Chemistry(2022)10.1016/j.jbc.2022.101728Source: DataRank Database

Structural and functional insights into the inhibition of human voltage-gated sodium channels by μ-conotoxin KIIIA disulfide isomers is a research paper published in Journal of Biological Chemistry (2022). On theSindex it has a DataRank of 0. It has been cited 21 times.

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Open Access21 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (7 grants)Impact (FWCI 1.41)OA: goldTopics (38)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (3)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (5)

Kirsten L. McMahon ORCID,Jennifer R. Deuis ORCID,Irina Vetter ORCID,Christina I. Schroeder ORCID,Hue N. T. Tran ORCID

Live enrichment

PubMed:35167877 PMC:PMC8927997 OpenAlex:https://openalex.org/W4211157960

Intramural NIH HHS

Grant: ZIA BC012003

Australian Research Council (ARC)

Grant: FT160100055

ARC Future Fellowships - Grant ID: FT160100055

National Health and Medical Research Council (NHMRC)

Grant: 2002860

Bivalent analgesics: rational design of selective ion channel inhibitors with optimised mechanism of action

National Health and Medical Research Council (NHMRC)

Grant: 1080405

Understanding how toxins interact with lipid membranes and ion channels

National Cancer Institute

Australian Research Council

National Health and Medical Research Council

FWCI

1.41

Citation Percentile

0.8%

Citation Trend

2022

2023

2024

2025

2026

goldLicense: cc-by-nc-nd

journalhttp://www.jbc.org/article/S0021925822001685/pdf

publisherhttp://www.jbc.org/article/S0021925822001685/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0021925822001685?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925822001685?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.jbc.2022.101728

Fields of Study

Nicotinic Acetylcholine Receptors StudyIon channel regulation and functionReceptor Mechanisms and Signaling0301 basic medicine03 medical and health sciences

MeSH Terms

DisulfidesHumansStructure-Activity RelationshipConotoxinsVoltage-Gated Sodium ChannelsVoltage-Gated Sodium Channel BlockersMolecular Docking Simulation

Keywords

ConotoxinChemistrySodium channelStereochemistryDisulfide bondPeptideSodiumBiochemistryOrganic chemistryVoltage-gated Sodium ChannelsNa(v)1.7KiiiaΜ-conotoxinDisulfide Bond IsomersVoltage-Gated Sodium Channel Blockers1303 BiochemistryCell Biology1307 Cell BiologyMolecular Docking SimulationStructure-Activity Relationship1312 Molecular BiologyHumansDisulfidesConotoxinsMolecular BiologyResearch Article

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Life below waterSDG 0: Clean water and sanitation

Structural and functional insights into the inhibition of human voltage-gated sodium channels by μ-conotoxin KIIIA disulfide isomers

FAIR Checklist

Authors (5)

Funding (7 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)