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Discovery of a small-molecule inhibitor of the TRIP8b–HCN interaction with efficacy in neurons

Journal of Biological Chemistry(2022)10.1016/j.jbc.2022.102069Source: DataRank Database

Discovery of a small-molecule inhibitor of the TRIP8b–HCN interaction with efficacy in neurons is a research paper published in Journal of Biological Chemistry (2022). On theSindex it has a DataRank of 0. It has been cited 8 times.

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Open Access8 citations

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Enrichment:Funding (37 grants)Impact (FWCI 0.64)OA: goldTopics (51)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (12)

Iredia D. Iyamu ORCID,Matthew R. Clutter,Rama K. Mishra ORCID,Kyle A. Lyman ORCID,Chengwen Zhou ORCID

Live enrichment

PubMed:35623388 PMC:PMC9243175 OpenAlex:https://openalex.org/W4281396785

University of Arizona Cancer Center

Grant: P30 CA060553

Vanderbilt Institute for Clinical and Translational Research

Grant: VR52450

Vanderbilt Institute for Clinical and Translational Research

Grant: VR53895

Vanderbilt-Ingram Cancer Center

Grant: P30 CA068485

Brain and Behavior Research Foundation

Grant: 25138

National Institutes of Health

Grant: CA68485

National Institutes of Health

Grant: DK20593

National Institutes of Health

Grant: DK58404

National Institutes of Health

Grant: DK59637

National Institutes of Health

Grant: EY08126

National Institutes of Health

Grant: HTS-004

National Institutes of Health

Grant: R01-NS059934

National Institutes of Health

Grant: R01MH106511

National Institutes of Health

Grant: R21MH104471

National Institutes of Health

Grant: R21MH113262

National Institutes of Health

Grant: R21MH126272

NIDDK NIH HHS

Grant: U24 DK059637

NIH HHS

Grant: S10 OD023681

NIDDK NIH HHS

Grant: P30 DK020593

NIDDK NIH HHS

Grant: P30 DK058404

NIMH NIH HHS

Grant: R56 MH128747

NINDS NIH HHS

Grant: R01 NS059934

NEI NIH HHS

Grant: P30 EY008126

National Institutes of Health

Grant: 5R21MH113262-03

Characterizing antidepressant-like effects of a novel peptide HCN channel inhibitor

National Institutes of Health

Grant: 1P30DK058404-01A1

CORE--MICROARRAY

National Institutes of Health

Grant: 2R01NS059934-06A1

HCN channel trafficking in epilepsy

National Institutes of Health

Grant: 1U24DK059637-01

CORE--METABOLIC PATHOPHYSIOLOGY

National Institutes of Health

Grant: 5R21MH126272-02

Investigating the Role of the Dorsal Hippocampus to Nucleus Accumbens Pathway in Regulating Social Interaction

National Institutes of Health

Grant: 5P30CA060553-12

The Robert H.Lurie Comprehensive Cancer Center

National Institutes of Health

Grant: 1R21MH104471-01A1

Evaluation of antidepressant-like effects of hippocampal HCN channel modulation

National Institutes of Health

Grant: 3P30CA068485-23S2

Cancer Center Support Grant

National Institutes of Health

Grant: 5P60DK020593-25

Diabetes Research and Training Center

National Institutes of Health

Grant: 7R01MH106511-03

Discovery of novel small molecule antidepressants

Chicago Biomedical Consortium

Robert H. Lurie Comprehensive Cancer Center

National Cancer Institute

Northwestern University

FWCI

0.64

Citation Percentile

0.6%

Citation Trend

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://doi.org/10.1016/j.jbc.2022.102069

publisherhttps://doi.org/10.1016/j.jbc.2022.102069

publisherhttps://api.elsevier.com/content/article/PII:S0021925822005099?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925822005099?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/35623388

Fields of Study

Neuroscience and Neuropharmacology ResearchReceptor Mechanisms and SignalingPharmacological Receptor Mechanisms and Effects0301 basic medicine0303 health sciences03 medical and health sciencesAnimalsCyclic Nucleotide-Gated Cation ChannelsMajor Depressive DisorderHippocampusHumansHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsMammalsNeurons

MeSH Terms

AnimalsMajor Depressive DisorderDepressive Disorder, MajorHippocampusHumansMammalsNeuronsCyclic Nucleotide-Gated Cation ChannelsHyperpolarization-Activated Cyclic Nucleotide-Gated Channels

Keywords

TetratricopeptideSmall moleculeChemistryIn vitroHCN channelMediatorProtein subunitNeuroscienceCell biologyPharmacologyBiologyIon channelBiochemistryGeneReceptorHippocampusMajor Depressive DisorderHcnI(h)Trip8bH CurrentMammalsNeuronsHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsAnimalsCyclic Nucleotide-Gated Cation ChannelsHumansResearch Article

Sustainable Development Goals

SDG 3: 3. Good health

Discovery of a small-molecule inhibitor of the TRIP8b–HCN interaction with efficacy in neurons

FAIR Checklist

Authors (12)

Funding (37 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)