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Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1

Journal of Biological Chemistry(2022)10.1016/j.jbc.2022.102209Source: DataRank Database

Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1 is a research paper published in Journal of Biological Chemistry (2022). On theSindex it has a DataRank of 0. It has been cited 7 times.

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Enrichment:Funding (12 grants)OA: goldTopics (49)IDs (PubMed)

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Authors (9)

Chun-Liang Chen ORCID,Sandeep K. Ravala ORCID,Jennifer N. Cash ORCID,Larisa Avramova,Mariya V. Zhalnina

Live enrichment

PubMed:35779635

National Institutes of Health

Grant: F31CA224804

National Institutes of Health

Grant: CA221289

National Institutes of Health

Grant: CA254402

National Institutes of Health

Grant: HL071818

National Institutes of Health

Grant: 5R01HL071818-08

Molecular basis for the regulation of G protein-coupled receptor kinases

National Institutes of Health

Grant: 5R01CA221289-03

GPCR - Linked RhoGEFs in Tumor Growth and Metastasis

European Commission

Grant: 221289

Coordinated Observational and Numerical Studies of InterStellar Tracers

National Institutes of Health

Grant: 1R01CA254402-01

Regulation of the metastasis promoting chemokine receptor ACKR3 by GPCR kinases, Gβγ and arrestins

National Institutes of Health

Grant: 1F31CA224804-01A1

Structure, Function, and Inhibition of the RhoGEF Trio - a Target in Uveal Melanoma

NCI NIH HHS

Grant: R01 CA221289

NCI NIH HHS

Grant: R01 CA254402

NHLBI NIH HHS

Grant: R01 HL071818

goldLicense: cc-by

GOLDhttp://www.jbc.org/article/S0021925822006512/pdf

publisherhttps://doi.org/10.1016/j.jbc.2022.102209

publisherhttps://api.elsevier.com/content/article/PII:S0021925822006512?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925822006512?httpAccept=text/plain

repositoryhttps://escholarship.org/uc/item/1v77b4zg

Fields of Study

MedicineBiologyChemistry0301 basic medicine03 medical and health sciences0303 health sciencesAnimalsCryoelectron MicroscopyGuanine Nucleotide Exchange FactorsHumansProtein BindingProtein Serine-Threonine KinasesRho Guanine Nucleotide Exchange FactorsSignal TransductionUveal Neoplasmsrac1 GTP-Binding Protein

MeSH Terms

AnimalsCryoelectron MicroscopyGuanine Nucleotide Exchange FactorsHumansProtein BindingProtein Serine-Threonine KinasesRho Guanine Nucleotide Exchange FactorsSignal TransductionUveal Neoplasmsrac1 GTP-Binding Protein

Keywords

Uveal Neoplasmsrac1 GTP-Binding Protein570610cryo-electron microscopyProtein Serine-Threonine KinasesDbl homologyguanine nucleotide exchange factor (GEF)Rhostructural biologyAnimalsGuanine Nucleotide Exchange FactorsHumansGTPaseCryoelectron Microscopypleckstrin homologyRacTriohydrogen-deuterium exchange mass spectrometryRho Guanine Nucleotide Exchange FactorsResearch ArticleProtein BindingSignal Transduction