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Single mutations toggle the substrate selectivity of multifunctional Camptotheca secologanic acid synthases

Journal of Biological Chemistry(2022)10.1016/j.jbc.2022.102237Source: DataRank Database

Single mutations toggle the substrate selectivity of multifunctional Camptotheca secologanic acid synthases is a research paper published in Journal of Biological Chemistry (2022). On theSindex it has a DataRank of 0. It has been cited 9 times.

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Open Access9 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (3 grants)Impact (FWCI 1.37)OA: goldTopics (50)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (2)

Mary A. Schuler ORCID,Justin C. Miller ORCID

Live enrichment

PubMed:35809640 PMC:PMC9424959 OpenAlex:https://openalex.org/W4284991174

National Institutes of Health

Grant: NRSA T-32-GM070421

NIGMS NIH HHS

Grant: T32 GM070421

National Institutes of Health

Grant: 5T32GM070421-09

Training Program in Chemistry-Interface with Biology

FWCI

1.37

Citation Percentile

0.8%

Citation Trend

2023

2024

2025

2026

goldLicense: cc-by

journalhttp://www.jbc.org/article/S0021925822006792/pdf

publisherhttp://www.jbc.org/article/S0021925822006792/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0021925822006792?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925822006792?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.jbc.2022.102237

Fields of Study

Alkaloids: synthesis and pharmacologyPlant biochemistry and biosynthesisMicrobial Natural Products and Biosynthesis0301 basic medicine0303 health sciences03 medical and health sciencesCamptothecaCytochrome P-450 Enzyme SystemHistidineIridoid GlucosidesIridoidsMutationOxidoreductases Acting on CH-CH Group DonorsTryptamines

MeSH Terms

Cytochrome P-450 Enzyme SystemHistidineMutationTryptaminesCamptothecaIridoidsOxidoreductases Acting on CH-CH Group DonorsIridoid Glucosides

Keywords

TryptamineBiochemistryLoganinChemistrySubfamilySubstrate (aquarium)BiologyStereochemistryGeneOrganic chemistryHomology modelingCamptotheca acuminataCytochrome p450secondary metabolismPlant BiochemistryEnzyme CatalysisEnzyme MutationAncestral Sequence ReconstructionNatural Product BiosynthesisOxidoreductases Acting on CH-CH Group DonorsCytochrome P-450 Enzyme SystemCamptothecaIridoid GlucosidesMutationHistidineIridoidsTryptaminesResearch Article

Sustainable Development Goals

SDG 0: Life in Land

Single mutations toggle the substrate selectivity of multifunctional Camptotheca secologanic acid synthases

FAIR Checklist

Authors (2)

Funding (3 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)