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Temperature-dependent hydrogen deuterium exchange shows impact of analog binding on adenosine deaminase flexibility but not embedded thermal networks

Journal of Biological Chemistry(2022)10.1016/j.jbc.2022.102350Source: DataRank Database

Temperature-dependent hydrogen deuterium exchange shows impact of analog binding on adenosine deaminase flexibility but not embedded thermal networks is a research paper published in Journal of Biological Chemistry (2022). On theSindex it has a DataRank of 0.460. It has been cited 13 times, with 5 citing works in its 1-hop citation network.

N/A

0.460DataRank · unranked

Scored on demand from live citation data

Open Access13 citations · 5 citing works in its network

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (5 grants)Impact (FWCI 0.94)OA: goldTopics (57)IDs (PubMed, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 86%Citation Network 14%

Base Score Contribution

0.396

From this paper's citation signal

Citation Network Contribution

0.0638

From 5 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 5 citers.

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Proceedings of the National Academy of Sciences202318 citations102 referencesContributes 0.029
Activation Heat Capacities in Pyridoxal Phosphate Enzymes
ACS Catalysis20242 citations67 referencesContributes 0.016
Examining DNA structures with in-droplet hydrogen/deuterium exchange mass spectrometry
International Journal of Mass Spectrometry20246 citations124 referencesContributes 0.016
Examining DNA Structures with In-droplet Hydrogen/Deuterium Exchange Mass Spectrometry
ChemRxiv20231 citations96 referencesContributes 0.007
Examining DNA Structures with In-droplet Hydrogen/Deuterium Exchange Mass Spectrometry
ChemRxiv20241 citations101 referencesContributes 0.007

Authors (5)

Wenju Zhang ORCID,Samuel L. Barrow,Anthony T. Iavarone,Judith P. Klinman ORCID,Shuaihua Gao ORCID

Live enrichment

PubMed:35933011 OpenAlex:https://openalex.org/W4289732098

National Institutes of Health

Grant: 1S10OD020062-01

High Definition Ion Mobility Spectrometer

National Institutes of Health

Grant: GM118117-015

National Institutes of Health

Grant: 5R35GM118117-08

Looking in New Directions for Origins and Cryptic Mechanisms of Enzyme Catalysis

NIGMS NIH HHS

Grant: R35 GM118117

NIH HHS

Grant: S10 OD020062

FWCI

0.94

Citation Percentile

0.7%

Citation Trend

2022

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://doi.org/10.1016/j.jbc.2022.102350

publisherhttps://doi.org/10.1016/j.jbc.2022.102350

publisherhttps://api.elsevier.com/content/article/PII:S0021925822007931?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925822007931?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/35933011

Fields of Study

Protein Structure and DynamicsMass Spectrometry Techniques and ApplicationsReceptor Mechanisms and Signaling0301 basic medicine03 medical and health sciences0303 health sciencesAdenosineAdenosine DeaminaseDeuteriumDeuterium Exchange MeasurementLigandsPentostatinProtein ConformationProteinsTemperature

MeSH Terms

AdenosineAdenosine DeaminaseDeuteriumLigandsProtein ConformationProteinsTemperaturePentostatinDeuterium Exchange Measurement

Keywords

ChemistryHydrogen–deuterium exchangeDeuteriumLigand (biochemistry)Adenosine deaminaseAdenosineBiophysicsMass spectrometryBiochemistryChromatographyBiologyReceptorPhysicsBiochemistry & Molecular BiologyBiomedical and clinical sciencesProtein ConformationLigands530Medical and Health SciencesAnalytical Chemistryconformational landscapeprotein flexibilityTemperaturethermal activationDeuterium Exchange MeasurementProteinstemperature-dependent hydrogen deuterium exchangeBiological Sciences540Chemical sciencesPentostatinResearch Articletemperature-dependent hydrogen deuterium exchange (TDHDX-MS)