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The role of FXR and TGR5 in reversing and preventing progression of Western diet–induced hepatic steatosis, inflammation, and fibrosis in mice

Journal of Biological Chemistry(2022)10.1016/j.jbc.2022.102530Source: DataRank Database

The role of FXR and TGR5 in reversing and preventing progression of Western diet–induced hepatic steatosis, inflammation, and fibrosis in mice is a research paper published in Journal of Biological Chemistry (2022). On theSindex it has a DataRank of 0. It has been cited 57 times.

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Scored on demand from live citation data

Open Access57 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (15 grants)Impact (FWCI 6.02)OA: goldTopics (95)IDs (PubMed, OpenAlex)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (25)

Cen Xie ORCID,Andrew E. Libby ORCID,Suman Ranjit ORCID,Jonathan Levi,Komuraiah Myakala ORCID

Live enrichment

PubMed:36209823 OpenAlex:https://openalex.org/W4302773679

National Institutes of Health

Grant: R01 AG049493

National Institutes of Health

Grant: DK116567

National Institute of General Medical Sciences

Grant: F30 DK129003

National Institute of General Medical Sciences

Grant: P41-GM103540

National Institute of General Medical Sciences

Grant: TL1 TR001431

National Institutes of Health

Grant: 3P41GM103540-29S1

Laboratory for Fluorescence Dynamics

National Institutes of Health

Grant: 5F30DK129003-04

Obeticholic acid as a novel treatment for Alport syndrome

National Institutes of Health

Grant: 1R01AG049493-01A1

Role of FXR and TGR5 in Age Related Renal Diseases

National Institutes of Health

Grant: 5TL1TR001431-09

Translational Biomedical Science Training Grant

National Institutes of Health

Grant: 1R01DK116567-01A1

Treatment of kidney disease in diabetes

NIDDK NIH HHS

Grant: P30 DK116073

NIDDK NIH HHS

Grant: R01 DK116567

NIGMS NIH HHS

Grant: P41 GM103540

NIDDK NIH HHS

Grant: T32 DK120521

NIDDK NIH HHS

Grant: P30 DK048520

FWCI

6.02

Citation Percentile

1.0%

Citation Trend

2022

2023

2024

2025

2026

goldLicense: cc-by-nc-nd

journalhttps://doi.org/10.1016/j.jbc.2022.102530

publisherhttps://doi.org/10.1016/j.jbc.2022.102530

publisherhttps://api.elsevier.com/content/article/PII:S0021925822009735?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925822009735?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/36209823

Fields of Study

Liver Disease Diagnosis and TreatmentDrug Transport and Resistance MechanismsLiver Diseases and Immunity0301 basic medicine0303 health sciences03 medical and health sciencesAnimalsMaleMiceBile Acids and SaltsCholesterolDiabetes Mellitus, Type 2Diet, WesternFatty AcidsFibrosisInflammationMice, Inbred C57BLMice, KnockoutNon-alcoholic Fatty Liver DiseaseReceptors, G-Protein-Coupled

MeSH Terms

AnimalsBile Acids and SaltsCholesterolDiabetes Mellitus, Type 2Fatty AcidsFibrosisInflammationMaleMice, Inbred C57BLMice, KnockoutReceptors, G-Protein-CoupledMiceNon-alcoholic Fatty Liver DiseaseDiet, Western

Keywords

Farnesoid X receptorG protein-coupled bile acid receptorInternal medicineSteatosisEndocrinologyNonalcoholic fatty liver diseaseBile acidObeticholic acidSteatohepatitisInflammationFatty liverHepatic fibrosisBiologyFibrosisNuclear receptorAgonistMedicineReceptorBiochemistryDiseaseMaleInbred C57BLMedical and Health SciencesOral and gastrointestinalHepatitisReceptors, G-Protein-CoupledMiceNon-alcoholic Fatty Liver DiseaseReceptorslipid metabolism2.1 Biological and endogenous factorsAetiologyMice, KnockoutLiver DiseaseFatty AcidsNASHBiological SciencesCholesterolFXR-TGR5WesternType 2Research Article570Biochemistry & Molecular BiologyKnockoutChronic Liver Disease and Cirrhosis610Bile Acids and SaltsG-Protein-CoupledDiabetes MellitusAnimalsObesityMetabolic and endocrineNutritionPreventionDietMice, Inbred C57BLDiabetes Mellitus, Type 2Diet, WesternChemical SciencesDigestive Diseases

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being