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Mutations in the α4-α5 allosteric lobe of RAS do not significantly impair RAS signaling or self-association

Journal of Biological Chemistry(2022)10.1016/j.jbc.2022.102661Source: DataRank Database

Mutations in the α4-α5 allosteric lobe of RAS do not significantly impair RAS signaling or self-association is a research paper published in Journal of Biological Chemistry (2022). On theSindex it has a DataRank of 0. It has been cited 15 times.

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Scored on demand from live citation data

Open Access15 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (20 grants)Impact (FWCI 1.01)OA: goldTopics (33)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (7)

Lauren Wallon ORCID,Megan Mazzei,Imran Khan ORCID,Kai Wen Teng ORCID,Shohei Koide ORCID

Live enrichment

PubMed:36334633 PMC:PMC9763690 OpenAlex:https://openalex.org/W4308550080

American Cancer Society

Grant: PF-18-180-01-TBE

US Department of Veterans Affairs

Grant: 1I01BX002095

National Cancer Institute

Grant: P30 CA138313

National Institutes of Health

Grant: GM132055

National Institutes of Health

Grant: F32 CA225131

National Institutes of Health

Grant: T32 GM 88118-10

National Institute of General Medical Sciences

Grant: R01 CA194864

National Institute of General Medical Sciences

Grant: P20 GM103542

National Institute of General Medical Sciences

Grant: R01CA212608

NIGMS NIH HHS

Grant: T32 GM132055

BLRD VA

Grant: I01 BX002095

NIGMS NIH HHS

Grant: R25 GM113278

National Institutes of Health

Grant: 7R01CA212608-02

Probing RAS-mediated signaling mechanisms with monobody inhibitors

National Institutes of Health

Grant: 1F32CA225131-01A1

Selective Inhibition of KRAS Mutants

National Institutes of Health

Grant: 5P20GM103542-10

South Carolina COBRE in Oxidants, Redox Balance and Stress Signaling

National Institutes of Health

Grant: 5T32GM088118-03

TRAINING PROGRAM IN MACROMOLECULAR STRUCTURE AND MECHANISM

National Institutes of Health

Grant: 1R01CA194864-01A1

Molecular mechanisms of SHP2 signaling dissected with designer binding proteins

National Institutes of Health

Grant: 7I01BX002095-05

Novel Functions for Ras family GTPases

National Institutes of Health

Grant: 5T32GM132055-05

Cellular, Biochemical and Molecular Sciences Training Program: Developing the skills and expertise needed for a changing biomedical landscape

National Institutes of Health

Grant: 5P30CA138313-09

Medical University of South Carolina - Cancer Center Support Grant

FWCI

1.01

Citation Percentile

0.7%

Citation Trend

2023

2024

2025

2026

goldLicense: cc-by

journalhttp://www.jbc.org/article/S0021925822011048/pdf

publisherhttp://www.jbc.org/article/S0021925822011048/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0021925822011048?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925822011048?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.jbc.2022.102661

Fields of Study

Protein Kinase Regulation and GTPase SignalingEnzyme Structure and FunctionProtein Structure and Dynamics0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

Guanosine TriphosphateHumansMutationProtein BindingGenes, rasSignal Transduction

Keywords

Allosteric regulationAssociation (psychology)Signal transductionMutationGeneticsBiologyCell biologyChemistryPsychologyReceptorGeneDimerizationoncogenesisGTPaseErk-mapkNanoclusteringGenes, rasHumansGuanosine TriphosphateResearch ArticleProtein Binding

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Mutations in the α4-α5 allosteric lobe of RAS do not significantly impair RAS signaling or self-association

FAIR Checklist

Authors (7)

Funding (20 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)