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Whole-genome CRISPR screening identifies PI3K/AKT as a downstream component of the oncogenic GNAQ–focal adhesion kinase signaling circuitry

Journal of Biological Chemistry(2022)10.1016/j.jbc.2022.102866Source: DataRank Database

Whole-genome CRISPR screening identifies PI3K/AKT as a downstream component of the oncogenic GNAQ–focal adhesion kinase signaling circuitry is a research paper published in Journal of Biological Chemistry (2022). On theSindex it has a DataRank of 0.434. It has been cited 17 times.

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0.434DataRank · unranked

Scored on demand from live citation data

Open Access17 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (14 grants)Impact (FWCI 2.94)OA: goldTopics (74)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.434

From this paper's citation signal

Citation Network Contribution

Citation network not refreshed for this result

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Authors (8)

Simone Lubrano ORCID,Damiano Cosimo Rigiracciolo ORCID,Daniela Nachmanson ORCID,Scott M. Lippman ORCID,Prashant Mali ORCID

Live enrichment

PubMed:36596361 OpenAlex:https://openalex.org/W4313398773

European Union's Research and Innovation

Grant: 101027731

New prECision thErapieS for uveal melanoma (targeting the Gαq/GNAQ oncogenic Signaling cIrcuiTrY)

European Union's Research and Innovation

Grant: 28DT-0011

European Union's Research and Innovation

Grant: 800924

International Cancer Research Fellowships - 2

Ministero dell’Istruzione, dell’Università e della Ricerca

Grant: 3407/2018

National Science Foundation

Grant: DGE-1650112

NIH

Grant: R01CA257505

NIH

Grant: T32GM007752

Melanoma Research Alliance

Grant: MRA827624

Department of Defense Peer Reviewed Cancer Research Program

Grant: W81XWH2110821

National Institutes of Health

Grant: 5U54CA209891-03

Research Center for Cancer Systems Biology: Cancer Cell Map Initiative

Ministero dell'Istruzione dell'Università e della Ricerca

Grant: unidentified

unidentified

National Institutes of Health

Grant: 5T32GM007752-12

CELLULAR AND MOLECULAR PHARMACOLOGY

National Institutes of Health

Grant: 5R01CA257505-05

Targeting Systems Vulnerabilities in the Gαq/GNAQ Oncogenic Signaling Circuitry: New Precision Therapies for Uveal Melanoma

NCI NIH HHS

Grant: U54 CA274502

FWCI

2.94

Citation Percentile

0.9%

Citation Trend

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://doi.org/10.1016/j.jbc.2022.102866

publisherhttps://doi.org/10.1016/j.jbc.2022.102866

publisherhttps://api.elsevier.com/content/article/PII:S0021925822013096?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925822013096?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/36596361

Fields of Study

Ocular Oncology and TreatmentsCell Adhesion Molecules ResearchCellular transport and secretion0301 basic medicine03 medical and health sciences0303 health sciencesSignal TransductionCarcinogenesisFocal Adhesion Protein-Tyrosine KinasesGTP-Binding Protein alpha Subunits, Gq-G11Clustered Regularly Interspaced Short Palindromic RepeatsProto-Oncogene Proteins c-aktGTP-Binding Protein alpha SubunitsUveal NeoplasmsHumansPhosphatidylinositol 3-KinasesMelanomaUveal Melanoma

MeSH Terms

Uveal MelanomaHumansMelanomaUveal NeoplasmsSignal TransductionPhosphatidylinositol 3-KinasesGTP-Binding Protein alpha Subunits, Gq-G11GTP-Binding Protein alpha SubunitsProto-Oncogene Proteins c-aktFocal Adhesion Protein-Tyrosine KinasesCarcinogenesisClustered Regularly Interspaced Short Palindromic Repeats

Keywords

PI3K/AKT/mTOR pathwayGNAQProtein kinase BSignal transductionBiologyCell biologyFocal adhesionReceptor tyrosine kinasePhosphorylationCancer researchCRISPRGeneticsMutationGeneUveal Neoplasms570Biochemistry & Molecular BiologyBiomedical and clinical sciencesCarcinogenesis1.1 Normal biological development and functioning610JBC CommunicationMedical and Health SciencesPhosphatidylinositol 3-KinasesRare DiseasesGNAQ/GNA11Protein phosphorylationUveal melanoma2.1 Biological and endogenous factorsHumansClustered Regularly Interspaced Short Palindromic RepeatsEye Disease and Disorders of VisionMelanomaCancerGq-G11FAKG proteinBiological SciencesGTP-Binding Protein alpha SubunitsChemical sciencesFocal Adhesion Protein-Tyrosine KinasesGTP-Binding Protein alpha Subunits, Gq-G11Biochemistry and Cell BiologyProto-Oncogene Proteins c-akt

Sustainable Development Goals

SDG 0: Good health and well-being