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A novel machine learning-based screening identifies statins as inhibitors of the calcium pump SERCA

Journal of Biological Chemistry(2023)10.1016/j.jbc.2023.104681Source: DataRank Database

A novel machine learning-based screening identifies statins as inhibitors of the calcium pump SERCA is a research paper published in Journal of Biological Chemistry (2023). On theSindex it has a DataRank of 0. It has been cited 12 times.

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Open Access12 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (5 grants)Impact (FWCI 1.71)OA: goldTopics (49)IDs (PubMed, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (6)

M. Andrés Velasco-Saavedra ORCID,Eli Fernández‐de Gortari,Guadalupe Guerrero‐Serna ORCID,Rodrigo Aguayo‐Ortiz ORCID,L. Michel Espinoza‐Fonseca ORCID

Live enrichment

PubMed:37030504 OpenAlex:https://openalex.org/W4362664012

Horizon 2020

Grant: 857253

Safety in NanOmaterials & NAnotechnology

National Heart Lung and Blood Institute

Grant: R01HL148068

National Institute of General Medical Sciences

Grant: R01GM120142

National Institutes of Health

Grant: 3R01GM120142-05S1

Molecular mechanisms and regulation of the calcium pump in the heart

National Institutes of Health

Grant: 5R01HL148068-02

Hit-to-lead optimization for heart failure drug discovery

FWCI

1.71

Citation Percentile

0.9%

Citation Trend

2023

2024

2025

2026

goldLicense: cc-by

journalhttp://www.jbc.org/article/S002192582300323X/pdf

publisherhttp://www.jbc.org/article/S002192582300323X/pdf

publisherhttps://api.elsevier.com/content/article/PII:S002192582300323X?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S002192582300323X?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.jbc.2023.104681

Fields of Study

Computational Drug Discovery MethodsCardiac electrophysiology and arrhythmiasLipoproteins and Cardiovascular Health03 medical and health sciences0303 health sciencesHydroxymethylglutaryl-CoA Reductase InhibitorsMyocardiumSarcoplasmic Reticulum Calcium-Transporting ATPasesMachine Learning

MeSH Terms

Machine LearningMyocardiumHydroxymethylglutaryl-CoA Reductase InhibitorsSarcoplasmic Reticulum Calcium-Transporting ATPases

Keywords

SERCACalciumComputer scienceCalcium pumpMachine learningChemistryPharmacologyComputational biologyArtificial intelligenceMedicineBiochemistryBiologyInternal medicineATPaseEnzymeDrug Target IdentificationSarcoplasmic Reticulum Calcium-Transporting ATPasesHealth SciencesCalcium SignalingMyocardiumMolecular Mechanisms of Cardiac ArrhythmiasCholesterol-lowering TreatmentComputational Theory and MathematicsPhysical SciencesSurgeryHydroxymethylglutaryl-CoA Reductase InhibitorsCardiology and Cardiovascular MedicineResearch ArticleComputational Methods in Drug Discoverycalcium ATPasedata augmentationdrug screeninginhibition mechanismmembrane proteinmolecular pharmacologystatins