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Contribution of the catalytic dyad of SARS-CoV-2 main protease to binding covalent and noncovalent inhibitors

Journal of Biological Chemistry(2023)10.1016/j.jbc.2023.104886Source: DataRank Database

Contribution of the catalytic dyad of SARS-CoV-2 main protease to binding covalent and noncovalent inhibitors is a research paper published in Journal of Biological Chemistry (2023). On theSindex it has a DataRank of 0. It has been cited 27 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access27 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (9 grants)Impact (FWCI 3.88)OA: goldTopics (67)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (6)

Annie Aniana ORCID,Leighton Coates ORCID,Peter V. Bonnesen ORCID,Nashaat T. Nashed ORCID,John M. Louis ORCID

Live enrichment

PubMed:37271339 PMC:PMC10238122 OpenAlex:https://openalex.org/W4379184262

National Institute of Diabetes and Digestive and Kidney Diseases

Grant: DK075166-01

National Institutes of Health

Grant: 1ZIADK013039-04

Molecular modeling of soluble proteins

National Institutes of Health

Grant: 1ZIADK075166-01

Biochemical and Structural Studies of Viral Proteases

Office of Science

Canadian Society for Molecular Biosciences

Biological and Environmental Research

National Institutes of Health

Oak Ridge National Laboratory

UT-Battelle

FWCI

3.88

Citation Percentile

0.9%

Citation Trend

2023

2024

2025

2026

goldLicense: cc-by-nc-nd

journalhttp://www.jbc.org/article/S0021925823019142/pdf

publisherhttp://www.jbc.org/article/S0021925823019142/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0021925823019142?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925823019142?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.jbc.2023.104886

Fields of Study

Computational Drug Discovery MethodsSARS-CoV-2 and COVID-19 ResearchProtein Structure and Dynamics0301 basic medicine03 medical and health sciencesHumansCarbonCoronavirus Protease InhibitorsCOVID-19LactamsLeucineMolecular Docking SimulationMolecular Dynamics SimulationNitrilesSARS-CoV-2Coronavirus 3C ProteasesIndazolesTriazinesTriazoles

MeSH Terms

Coronavirus Protease InhibitorsCOVID-19SARS-CoV-2Coronavirus 3C ProteasesCarbonHumansIndazolesLactamsLeucineNitrilesTriazinesTriazolesMolecular Dynamics SimulationMolecular Docking Simulation

Keywords

Covalent bondChemistryStereochemistryNucleophileNon-covalent interactionsBinding siteDissociation constantCrystallographyCatalysisHydrogen bondBiochemistryMoleculeOrganic chemistryThermal stabilityRoom-temperature X-ray CrystallographySars-cov-2 Main ProteaseMain Protease InhibitorsC145a/h41a MutationsInhibitor Binding ThermodynamicsIndazolesLactamsSARS-CoV-2TriazinesCOVID-19Molecular Dynamics SimulationTriazolesCarbonMolecular Docking SimulationCoronavirus Protease InhibitorsLeucineNitrilesHumansCoronavirus 3C ProteasesResearch Article

Sustainable Development Goals

SDG 0: Affordable and clean energy

Contribution of the catalytic dyad of SARS-CoV-2 main protease to binding covalent and noncovalent inhibitors

FAIR Checklist

Authors (6)

Funding (9 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)