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Gαs is dispensable for β-arrestin coupling but dictates GRK selectivity and is predominant for gene expression regulation by β2-adrenergic receptor

Journal of Biological Chemistry(2023)10.1016/j.jbc.2023.105293Source: DataRank Database

Gαs is dispensable for β-arrestin coupling but dictates GRK selectivity and is predominant for gene expression regulation by β2-adrenergic receptor is a research paper published in Journal of Biological Chemistry (2023). On theSindex it has a DataRank of 0. It has been cited 15 times.

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Enrichment:Funding (20 grants)OA: goldTopics (55)IDs (PubMed, PMC)Annotations (1)

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Authors (16)

Justine S. Paradis,Adam Officer ORCID,Sendi Rafael Adame-Garcia ORCID,Xingyu Wu ORCID,Edda S. F. Matthees ORCID

Live enrichment

PubMed:37774973 PMC:PMC10641165

Japan Society for the Promotion of Science

Grant: JP22ama121038

Japan Society for the Promotion of Science

Grant: JP22zf0127007

Japan Science and Technology Agency

Grant: 22714181

Japan Science and Technology Agency

Grant: JPMJFR215T

Japan Science and Technology Agency

Grant: JPMJMS2023

National Institutes of Health

Grant: R21 CA 273974

National Institutes of Health

Grant: U54 CA274502

U.S. National Library of Medicine

Grant: JP21H04791

U.S. National Library of Medicine

Grant: JP21H05037

U.S. National Library of Medicine

Grant: JP21H05113

U.S. National Library of Medicine

Grant: T15LM011271

NCI NIH HHS

Grant: U54 CA209891

NIDA NIH HHS

Grant: R01 DA010711

NIDA NIH HHS

Grant: R01 DA012864

NIMH NIH HHS

Grant: R01 MH120212

NCI NIH HHS

Grant: U24 CA220341

National Institutes of Health

Grant: 5U54CA209891-03

Research Center for Cancer Systems Biology: Cancer Cell Map Initiative

National Institutes of Health

Grant: 1U54CA274502-01

The Cancer Cell Map Initiative v2.0

National Institutes of Health

Grant: 2T15LM011271-11

San Diego Biomedical Informatics Education & Research (SABER)

Japan Agency for Medical Research and Development

goldLicense: cc-by

publisherhttp://www.jbc.org/article/S0021925823023219/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0021925823023219?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925823023219?httpAccept=text/plain

repositoryhttps://escholarship.org/content/qt6f859559/qt6f859559.pdf

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC10641165/pdf/main.pdf

Fields of Study

0301 basic medicine03 medical and health sciences

MeSH Terms

HumansGTP-Binding ProteinsGTP-Binding Protein alpha SubunitsCyclic AMP-Dependent Protein KinasesMitogen-Activated Protein KinasesReceptors, Adrenergic, beta-2Protein IsoformsGene Expression RegulationEnzyme ActivationProtein Structure, TertiaryPhosphorylationHEK293 Cellsbeta-Arrestinsbeta-Arrestin 1beta-Arrestin 2

Keywords

G proteinSignalingGene ExpressionG Protein–coupled ReceptorΒ-arrestin570Protein StructureBiochemistry & Molecular BiologyBiomedical and clinical sciences1.1 Normal biological development and functioningbeta-2Medical and Health SciencesGTP-Binding ProteinsReceptorsGenetics2.1 Biological and endogenous factorsHumansProtein IsoformsPhosphorylationbeta-ArrestinsInflammatory and immune systemBiological Sciencesbeta-Arrestin 2Cyclic AMP-Dependent Protein KinasesGTP-Binding Protein alpha SubunitsProtein Structure, TertiaryEnzyme Activationbeta-Arrestin 1HEK293 CellsChemical sciencesGene Expression RegulationAdrenergicBiochemistry and Cell BiologyGeneric health relevanceReceptors, Adrenergic, beta-2Mitogen-Activated Protein KinasesTertiaryResearch Article

Gαs is dispensable for β-arrestin coupling but dictates GRK selectivity and is predominant for gene expression regulation by β2-adrenergic receptor

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Authors (16)

Funding (20 grants)

Open Access

Topics

Annotations (Europe PMC)