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Molecular mechanism of EAG1 channel inhibition by imipramine binding to the PAS domain

Journal of Biological Chemistry(2023)10.1016/j.jbc.2023.105391Source: DataRank Database

Molecular mechanism of EAG1 channel inhibition by imipramine binding to the PAS domain is a research paper published in Journal of Biological Chemistry (2023). On theSindex it has a DataRank of 0. It has been cited 14 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access14 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (5 grants)Impact (FWCI 1.29)OA: goldTopics (30)IDs (PubMed, PMC, OpenAlex)Annotations (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (6)

Mahdi Ghorbani ORCID,Xi Chen ORCID,Purushottam B. Tiwari ORCID,Jeffery B. Klauda ORCID,Tinatin I. Brelidze ORCID

Live enrichment

PubMed:37898402 PMC:PMC10687071 OpenAlex:https://openalex.org/W4388007267

National Science Foundation

Grant: BIO220104

National Cancer Institute

Grant: R01CA252969

National Cancer Institute

Grant: P30CA51008

National Institute of General Medical Sciences

Grant: R01GM124020

NCI NIH HHS

Grant: P30 CA051008

FWCI

1.29

Citation Percentile

0.8%

Citation Trend

2023

2024

2026

goldLicense: cc-by

journalhttp://www.jbc.org/article/S0021925823024195/pdf

publisherhttp://www.jbc.org/article/S0021925823024195/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0021925823024195?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925823024195?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.jbc.2023.105391

Fields of Study

Ion channel regulation and functionReceptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

MeSH Terms

Protein DomainsAnimalsImipramineProtein BindingXenopusMiceEther-A-Go-Go Potassium ChannelsElectrophysiological Phenomena

Keywords

BiophysicsChemistryImipramineBinding siteMutagenesisMolecular switchBiochemistryStereochemistryMutationBiologyMoleculeInhibitorGatingEAGpotassium channelLigand-binding ProteinKcnh1Inhibition MechanismKv10.1 Channels