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Combined inhibition of MTAP and MAT2a mimics synthetic lethality in tumor models via PRMT5 inhibition

Journal of Biological Chemistry(2023)10.1016/j.jbc.2023.105492Source: DataRank Database

Combined inhibition of MTAP and MAT2a mimics synthetic lethality in tumor models via PRMT5 inhibition is a research paper published in Journal of Biological Chemistry (2023). On theSindex it has a DataRank of 0.529. It has been cited 33 times.

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0.529DataRank · unranked

Scored on demand from live citation data

Open Access33 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (19 grants)Impact (FWCI 3.13)OA: goldTopics (80)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.529

From this paper's citation signal

Citation Network Contribution

Citation network not refreshed for this result

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Authors (10)

Nord Gilaj,Karina Peregrina ORCID,Isabella Brew,Elena Tosti ORCID,Karl J. Shaffer

Live enrichment

PubMed:38000655 PMC:PMC10770533 OpenAlex:https://openalex.org/W4388934818

National Cancer Institute

Grant: CA013330

National Cancer Institute

Grant: CA135405

National Cancer Institute

Grant: CA214625

National Cancer Institute

Grant: CA275213

National Institute of General Medical Sciences

Grant: GM007288

National Institute of General Medical Sciences

Grant: GM041916

NCI NIH HHS

Grant: P30 CA013330

NIGMS NIH HHS

Grant: R37 GM041916

NCI NIH HHS

Grant: F30 CA275213

NCI NIH HHS

Grant: R01 CA135405

NCI NIH HHS

Grant: R01 CA214625

NIGMS NIH HHS

Grant: R01 GM041916

NIGMS NIH HHS

Grant: T32 GM007288

National Institutes of Health

Grant: 2T32GM007288-24

MEDICAL SCIENTIST TRAINING PROGRAM

National Institutes of Health

Grant: 5R01CA214625-03

A Major Nutritional Effect on Intestinal Stem Cells and Tumors

National Institutes of Health

Grant: 5F30CA275213-02

Rational design of anti-cancer therapeutics harnessing the synthetic lethality of methionine metabolism and arginine methyltransferases

National Institutes of Health

Grant: 5R01CA135405-05

Transition State Analogues as Modulators of DNA Methylation

National Institutes of Health

Grant: 5R01GM041916-30

Transition State Analysis of Enzymatic Reactions

National Institutes of Health

FWCI

3.13

Citation Percentile

0.9%

Citation Trend

2024

2025

2026

goldLicense: cc-by

journalhttp://www.jbc.org/article/S0021925823025206/pdf

publisherhttp://www.jbc.org/article/S0021925823025206/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0021925823025206?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925823025206?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.jbc.2023.105492

Fields of Study

Cancer-related gene regulationEpigenetics and DNA Methylation03 medical and health sciences0302 clinical medicineAnimalsHumansMiceCell Line, TumorCell ProliferationDeoxyadenosinesDrug SynergismEnzyme InhibitorsMethionine AdenosyltransferaseNeoplasmsProtein-Arginine N-MethyltransferasesProto-Oncogene ProteinsPurine-Nucleoside PhosphorylasePyrrolidinesS-Adenosylmethionine

MeSH Terms

Synthetic Lethal MutationsAnimalsDeoxyadenosinesDrug SynergismEnzyme InhibitorsHumansMethionineMethionine AdenosyltransferaseNeoplasmsProtein-Arginine N-MethyltransferasesProto-Oncogene ProteinsPurine-Nucleoside PhosphorylasePyrrolidinesS-AdenosylmethionineThionucleosidesCell Cycle ProteinsCell Line, TumorCell ProliferationMice

Keywords

Synthetic lethalityMethionine AdenosyltransferaseMethionineCancer researchCell cultureProgrammed cell deathMethyltransferaseCellApoptosisChemistryCell growthBiologyPharmacologyBiochemistryMethylationGeneticsAmino acidGeneDNA repairColorectal CancerS-adenosyl-L-methionineCancer MetabolismPrmt5Arginine MethylationMtapMat2a5'-MethylthioadenosineProtein-Arginine N-MethyltransferasesS-AdenosylmethioninePyrrolidinesDeoxyadenosinesDrug SynergismMicePurine-Nucleoside PhosphorylaseCell Line, TumorNeoplasmsProto-Oncogene ProteinsAnimalsHumansEnzyme InhibitorsResearch ArticleCell Proliferation

Sustainable Development Goals

SDG 0: Good health and well-being