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Triclosan administration to humanized UDP-glucuronosyltransferase 1 neonatal mice induces UGT1A1 through a dependence on PPARα and ATF4

Journal of Biological Chemistry(2024)10.1016/j.jbc.2024.107340Source: DataRank Database

Triclosan administration to humanized UDP-glucuronosyltransferase 1 neonatal mice induces UGT1A1 through a dependence on PPARα and ATF4 is a research paper published in Journal of Biological Chemistry (2024). On theSindex it has a DataRank of 0. It has been cited 4 times.

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Open Access4 citations

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Enrichment:Funding (4 grants)Impact (FWCI 1.75)OA: goldTopics (59)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (13)

Xiaojing Yang ORCID,Elvira Mennillo ORCID,Samantha Wong ORCID,Sabrina Le,Jia Ying Ashley Teo

Live enrichment

PubMed:38705390 PMC:PMC11152660 OpenAlex:https://openalex.org/W4396641166

National Institutes of Health

Grant: 3P42ES010337-20S1

Harnessing Technological Innovation and Community-Engaged Implementation Science to Optimize COVID-19 Testing for Women and Children in Underserved Communities

National Institutes of Health

Grant: 1R21ES034630-01

APOB48 downregulation is the causing factor in mediating iAs-induced lipid accumulation in enterocytes

National Institutes of Health

Grant: 5R01DK136599-03

Severe neonatal hyperbilirubinemia (SNH) and the expression of UDP-glucuronosyltransferase 1A1 (UGT1A1) play key roles in the development of necrotizing enterocolitis (NEC)

National Institutes of Health

Grant: 1R21ES031849-01A1

Lifelong Triclosan Exposure and Fatty Liver Disease

FWCI

1.75

Citation Percentile

0.8%

Citation Trend

2025

2026

goldLicense: cc-by

journalhttps://www.jbc.org/article/S0021-9258(24)01841-6/pdf

publisherhttps://www.jbc.org/article/S0021-9258(24)01841-6/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0021925824018416?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925824018416?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.jbc.2024.107340

Fields of Study

Pharmacogenetics and Drug MetabolismEffects and risks of endocrine disrupting chemicalsAdipose Tissue and Metabolism0301 basic medicine03 medical and health sciences

MeSH Terms

Constitutive Androstane ReceptorUGT1A1 EnzymeAnimalsAnimals, NewbornBilirubinFemaleHumansLiverTriclosanGlucuronosyltransferaseReceptors, Cytoplasmic and NuclearMice, KnockoutPPAR alphaMiceActivating Transcription Factor 4

Keywords

Constitutive androstane receptorAndrostaneInternal medicineBilirubinPeroxisome proliferator-activated receptorEndocrinologyToxicantTriclosanNuclear receptorReceptorChemistryPharmacologyTranscription factorBiologyMedicineToxicityBiochemistryGeneCytochrome P450 (Cyp)Peroxisome Proliferator-activated Receptor Alpha (Pparα)Constitutive Androstane Receptor (Car)Activating Transcription Factor 4 (Atf4)Integrated Stress Response (Isr)Uridine 5'-Diphospho-glucuronosyltransferase (Ugt)Humanized Ugt1 (Hugt1)Total Serum Bilirubin (Tsb)Mice, KnockoutReceptors, Cytoplasmic and NuclearActivating Transcription Factor 4MiceAnimals, NewbornLiverAnimalsHumansPPAR alphaFemaleGlucuronosyltransferaseUGT1A1 EnzymeResearch Article

Sustainable Development Goals

SDG 0: Zero hunger

Triclosan administration to humanized UDP-glucuronosyltransferase 1 neonatal mice induces UGT1A1 through a dependence on PPARα and ATF4

FAIR Checklist

Authors (13)

Funding (4 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)