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Recombinant antibodies inhibit enzymatic activity of the E3 ubiquitin ligase CHIP via multiple mechanisms

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.108220Source: DataRank Database

Recombinant antibodies inhibit enzymatic activity of the E3 ubiquitin ligase CHIP via multiple mechanisms is a research paper published in Journal of Biological Chemistry (2025). On theSindex it has a DataRank of 0. It has been cited 2 times.

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Open Access2 citations

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Enrichment:Funding (11 grants)Impact (FWCI 0.77)OA: goldTopics (56)IDs (PubMed, PMC, OpenAlex)Annotations (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (9)

Emily J. Connelly ORCID,Aparna Unnikrishnan ORCID,Shih‐Wei Chuo ORCID,Kristin Wucherer ORCID,Cory M. Nadel ORCID

Live enrichment

PubMed:39863102 PMC:PMC11883360 OpenAlex:https://openalex.org/W4406757333

National Institute of Neurological Disorders and Stroke

Grant: R01NS059690

National Institute of Allergy and Infectious Diseases Division of Intramural Research

Grant: U54AI170792

National Institute on Aging

Grant: RF1AG068125

Alzheimer's Association

Grant: AARF-22-974237

NIGMS NIH HHS

Grant: R01 GM138690

NIA NIH HHS

Grant: R01 AG068125

National Institutes of Health

Grant: 1RF1AG068125-01

Probing the Role of Chaperone-TPR Complexes in Tau Proteostasis

National Institutes of Health

Grant: 1U54AI170792-01

HARC: HIV accessory and regulatory complexes

National Institutes of Health

Grant: 5R01NS059690-10

Molecular Chaperones and Small Molecules

National Institutes of Health

University of California, San Francisco

FWCI

0.77

Citation Percentile

0.7%

Citation Trend

2025

goldLicense: cc-by-nc-nd

journalhttps://www.jbc.org/article/S0021-9258(25)00067-5/pdf

publisherhttps://www.jbc.org/article/S0021-9258(25)00067-5/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0021925825000675?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925825000675?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.jbc.2025.108220

Fields of Study

Ubiquitin and proteasome pathwaysProtein Degradation and InhibitorsCAR-T cell therapy researchMedicineBiologyChemistry0301 basic medicine03 medical and health sciencesUbiquitin-Protein LigasesHumansRecombinant ProteinsUbiquitinationCryoelectron MicroscopyImmunoglobulin Fab Fragments

MeSH Terms

HumansImmunoglobulin Fab FragmentsRecombinant ProteinsCryoelectron MicroscopyUbiquitin-Protein LigasesUbiquitination

Keywords

Ubiquitin ligaseRecombinant DNADNA ligaseUbiquitinEnzymeChemistryAntibodyBiochemistryUbiquitin-Protein LigasesMolecular biologyCell biologyBiologyGeneImmunologyUbiquitinationCryo-electron microscopyE3 ubiquitin ligaseRecombinant Antibodyprotein-protein interactionsAutoubiquitinationCarboxyl-terminus Of Hsp70-interacting Protein (Chip)Biochemistry & Molecular BiologyBiomedical and clinical sciences1.1 Normal biological development and functioningMedical and Health SciencesImmunoglobulin Fab Fragments2.1 Biological and endogenous factorsHumansCancercarboxyl-terminus of Hsp70-Interacting proteinCryoelectron MicroscopyBiological SciencesRecombinant ProteinsChemical sciencesBiochemistry and Cell BiologyBiotechnology