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Structural and functional analysis of cancer-associated missense variants in the retinoblastoma protein pocket domain

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.108284Source: DataRank Database

Structural and functional analysis of cancer-associated missense variants in the retinoblastoma protein pocket domain is a research paper published in Journal of Biological Chemistry (2025). On theSindex it has a DataRank of 0.219. It has been cited 2 times, with 2 citing works in its 1-hop citation network.

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0.219DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access2 citations · 2 citing works in its network

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Linked data & code

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Data availability

Repositories this paper deposited data in (declared in PubMed).

PDB9DHU 9DHF 9DGK 9DHC

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (5 grants)Impact (FWCI 0.98)OA: goldTopics (59)IDs (PubMed, PMC, OpenAlex)Annotations (3)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 75%Citation Network 25%

Base Score Contribution

0.165

From this paper's citation signal

Citation Network Contribution

0.0538

From 2 citing papers with measurable signal

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Top 2 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 2 citers.

A functional assay to classify RB1 variants of uncertain significance
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Biochimica et Biophysica Acta (BBA) - Reviews on Cancer20259 citations167 referencesContributes 0.014

Authors (14)

Alfredo Ruiz-Rivera ORCID,Chad C Moorman ORCID,Emma R Wolf-Saxon ORCID,Hailey N Mims,Vanessa I Vasquez-Meza

Live enrichment

PubMed:39938803 PMC:PMC11931385 OpenAlex:https://openalex.org/W4407318224

NIH National Institute of General Medical Sciences

Grant: SC3GM135037

NCI NIH HHS

Grant: P01 CA254867

NIGMS NIH HHS

Grant: R35 GM145255

National Institutes of Health

Grant: 1SC3GM135037-01

Biochemical Classification of Cancer Missense Mutations in the Retinoblastoma Protein

National Institutes of Health

FWCI

0.98

Citation Percentile

0.7%

Citation Trend

2025

goldLicense: cc-by

journalhttps://www.jbc.org/article/S0021-9258(25)00132-2/pdf

publisherhttps://www.jbc.org/article/S0021-9258(25)00132-2/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0021925825001322?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925825001322?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.jbc.2025.108284

Fields of Study

Cancer-related Molecular PathwaysUbiquitin and proteasome pathwaysDNA Repair Mechanisms0301 basic medicine03 medical and health sciencesMutation, MissenseHumansRetinoblastoma ProteinProtein DomainsNeoplasmsProtein BindingBinding SitesModels, Molecular

MeSH Terms

Protein DomainsBinding SitesHumansModels, MolecularNeoplasmsProtein BindingRetinoblastoma ProteinMutation, Missense

Keywords

Missense mutationRetinoblastomaGeneticsBiologyCancerCancer researchComputational biologyChemistryMutationGeneCell cycleFluorescence anisotropyTumor suppressor geneCrystal structureProtein StabilityE2f Transcription FactorRetinoblastoma Protein (Prb, Rb)Models, MolecularBiochemistry & Molecular BiologyBiomedical and clinical sciencesBioinformatics and Computational BiologyMutation, Missenseretinoblastoma proteinMedical and Health SciencesRare DiseasesProtein DomainsModelsNeoplasms2.1 Biological and endogenous factorsHumansBinding SitesMolecularBiological SciencesChemical sciencesBiochemistry and Cell BiologyMissenseResearch ArticleProtein Binding

Sustainable Development Goals

SDG 0: Good health and well-being