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PKM splice-switching ASOs induce upregulation of dual-specificity phosphatases and dephosphorylation of ERK1/2 in hepatocellular carcinoma

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.108345Source: DataRank Database

PKM splice-switching ASOs induce upregulation of dual-specificity phosphatases and dephosphorylation of ERK1/2 in hepatocellular carcinoma is a research paper published in Journal of Biological Chemistry (2025). On theSindex it has a DataRank of 0. It has been cited 7 times.

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Enrichment:Funding (23 grants)OA: goldTopics (41)IDs (PubMed, PMC)Annotations (2)

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Authors (12)

Alexander J. Kral ORCID,GeunYoung Sim ORCID,Raditya Utama ORCID,Kuan‐Ting Lin ORCID,Chris Cizmeciyan

Live enrichment

PubMed:39993527 PMC:PMC11982463

Cold Spring Harbor Laboratory

Grant: R01AA023146

Cold Spring Harbor Laboratory

Grant: U01 CA230690

Cold Spring Harbor Laboratory

Grant: 5P30CA045508

Cold Spring Harbor Laboratory

Grant: R01CA236591

NIH National Institute of General Medical Sciences

Grant: 5T32GM008444

National Institutes of Health

Grant: 5F31CA278591

National Institutes of Health National Cancer Institute

Grant: F30CA271804

National Institutes of Health National Cancer Institute

Grant: CA229699

National Institutes of Health National Cancer Institute

Grant: CA13106

NCI NIH HHS

Grant: F31 CA278591

NCI NIH HHS

Grant: P01 CA013106

NCI NIH HHS

Grant: P30 CA045508

NCI NIH HHS

Grant: R01 CA229699

National Institutes of Health

Grant: 5F30CA271804-04

Inducing PKM splice-switching with antisense oligonucleotides as an approach to treat hepatocellular carcinoma

National Institutes of Health

Grant: 5U01CA230690-04

Pathway Specific Functional Biomarkers for the Early Detection of Liver Cancer

National Institutes of Health

Grant: 5F31CA278591-03

Targeting of Krüppel-like Factor 5 (KLF5) in Pancreatic Ductal Adenocarcinoma

National Institutes of Health

Grant: 2P01CA013106-31

PROTEOLYTIC CONTROL OF ONCOPROTEIN FUNCTION

National Institutes of Health

Grant: 5R01CA236591-02

Cellular interactions between TGF-beta pathway members and epignetic regulators in liver and gastrointestinal cancers

National Institutes of Health

Grant: 2T32GM008444-24

Medical Scientist Training Program

National Institutes of Health

Grant: 3P30CA045508-08S1

CSHL CANCER CENTER SUPPORT GRANT

National Institutes of Health

Grant: 7R01AA023146-16

Role of Beta Spectrin and Smad in Alcohol Induced Liver and GI Cell Proliferation

National Institutes of Health

Grant: 5R01CA229699-04

Targeting aberrant enhancer landscapes in pancreatic cancer

University of Colorado Boulder

goldLicense: cc-by

publisherhttps://www.jbc.org/article/S0021-9258(25)00194-2/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0021925825001942?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925825001942?httpAccept=text/plain

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/11982463

Europe_PMChttps://europepmc.org/articles/PMC11982463

Fields of Study

0301 basic medicine03 medical and health sciences

MeSH Terms

Cell Line, TumorHumansCarcinoma, HepatocellularLiver NeoplasmsThyroid HormonesMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Pyruvate KinaseMembrane ProteinsOligonucleotides, AntisenseCell ProliferationMAP Kinase Signaling SystemGene Expression Regulation, NeoplasticAlternative SplicingUp-RegulationPhosphorylationThyroid Hormone-Binding Proteins

Keywords

CancerAntisense RNAHepatocellular carcinomaPyruvate kinaseDual-specificity Phosphoprotein PhosphataseMitogen-Activated Protein Kinase 1Thyroid HormonesCarcinoma, HepatocellularMitogen-Activated Protein Kinase 3MAP Kinase Signaling SystemLiver NeoplasmsMembrane ProteinsOligonucleotides, AntisenseUp-RegulationGene Expression Regulation, NeoplasticAlternative SplicingCell Line, TumorHumansPhosphorylationResearch ArticleCell ProliferationThyroid Hormone-Binding Proteins

PKM splice-switching ASOs induce upregulation of dual-specificity phosphatases and dephosphorylation of ERK1/2 in hepatocellular carcinoma

FAIR Checklist

Authors (12)

Funding (23 grants)

Open Access

Topics

Annotations (Europe PMC)