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Inactivation of SIAH-1 E3 ligase attenuates Aβ toxicity by suppressing ubiquitin-dependent DVE-1 degradation in Caenorhabditis elegans models of Alzheimer’s disease

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110226Source: DataRank Database

Inactivation of SIAH-1 E3 ligase attenuates Aβ toxicity by suppressing ubiquitin-dependent DVE-1 degradation in Caenorhabditis elegans models of Alzheimer’s disease is a research paper published in Journal of Biological Chemistry (2025). On theSindex it has a DataRank of 0. It has been cited 2 times.

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Enrichment:Funding (9 grants)OA: goldTopics (37)IDs (PubMed, PMC)Annotations (1)

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Authors (8)

Jiahui Liu ORCID,Mingxia Lu ORCID,Yingying Zhou ORCID,Shuqi Guo,Zhipeng Qin

Live enrichment

PubMed:40349774 PMC:PMC12179603

National Natural Science Foundation of China

Grant: 31601091

Henan Province Natural Science Foundation

Grant: 212300410330

National Natural Science Foundation of China

Grant: 31970166

National Institutes of Health

Grant: P40 OD010440

Institute of Genetics and Developmental Biology, Chinese Academy of Sciences

Grant: syb4782

National Natural Science Foundation of China

Grant: 32470176

National Institutes of Health

Grant: 1P40OD010440-01

Caenorhabditis Genetics Center

Yunnan University

Shanxi Normal University

goldLicense: cc-by

publisherhttps://www.jbc.org/action/showPdf?pii=S0021925825020769

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/12179603

Europe_PMChttps://europepmc.org/articles/PMC12179603

Europe_PMChttps://europepmc.org/articles/PMC12179603?pdf=render

https://doi.org/10.1016/j.jbc.2025.110226

Fields of Study

03 medical and health sciences0302 clinical medicine

MeSH Terms

MitochondriaAnimalsHumansCaenorhabditis elegansAlzheimer DiseaseDisease Models, AnimalUbiquitin-Protein LigasesCaenorhabditis elegans ProteinsUbiquitinUbiquitinationUnfolded Protein ResponseAmyloid beta-PeptidesProteolysisSeven in Absentia Proteins

Keywords

C. ElegansProteasomal DegradationAβ ToxicityUpr(mt)Dve-1E3 Ubiquitin Ligase Siah-1Amyloid beta-PeptidesUbiquitinUbiquitin-Protein LigasesUbiquitinationMitochondriaDisease Models, AnimalAlzheimer DiseaseProteolysisUnfolded Protein ResponseAnimalsHumansCaenorhabditis elegansCaenorhabditis elegans ProteinsSeven in Absentia ProteinsResearch Article

Inactivation of SIAH-1 E3 ligase attenuates Aβ toxicity by suppressing ubiquitin-dependent DVE-1 degradation in Caenorhabditis elegans models of Alzheimer’s disease

FAIR Checklist

Authors (8)

Funding (9 grants)

Open Access

Topics

Annotations (Europe PMC)