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A SUMO-interacting motif in the guanine nucleotide exchange factor EPAC1 is required for subcellular targeting and function

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110279Source: DataRank Database

A SUMO-interacting motif in the guanine nucleotide exchange factor EPAC1 is required for subcellular targeting and function is a research paper published in Journal of Biological Chemistry (2025). On theSindex it has a DataRank of 0. It has been cited 3 times.

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Open Access3 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (10 grants)Impact (FWCI 1.14)OA: goldTopics (53)IDs (PubMed, PMC, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (8)

Fang Mei ORCID,Wei Lin ORCID,Jason E. Lee ORCID,Si Nie ORCID,Christopher J. Bley ORCID

Live enrichment

PubMed:40412525 PMC:PMC12226364 OpenAlex:https://openalex.org/W4410616502

National Eye Institute

Grant: R01EY033319

NIH National Institute of General Medical Sciences

Grant: R35GM122536

National Institute of Diabetes and Digestive and Kidney Diseases

Grant: R01DK136462

National Institute of Child Health and Human Development

Grant: Nup358 HCT116

National Institutes of Health

Grant: R01GM117360

National Institutes of Health

Grant: 3R01EY033319-03S1

Epac1 as a novel therapeutic target for diabetic retinopathy

National Institutes of Health

Grant: 1R01GM117360-01

Molecular Basis of mRNA Export

National Institutes of Health

Grant: 5R01DK136462-02

Significance of Epac signaling in renal Na+handling and hypertension

National Institutes of Health

Grant: 1R35GM122536-01

Exchange Protein directly Activated by cAMP (EPAC): Structure, Function and Therapeutics

Howard Hughes Medical Institute

FWCI

1.14

Citation Percentile

0.8%

Citation Trend

2025

2026

goldLicense: cc-by

journalhttps://doi.org/10.1016/j.jbc.2025.110279

publisherhttps://doi.org/10.1016/j.jbc.2025.110279

publisherhttps://api.elsevier.com/content/article/PII:S0021925825021295?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925825021295?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40412525

Fields of Study

Ubiquitin and proteasome pathwaysATP Synthase and ATPases ResearchGlycosylation and Glycoproteins Research0301 basic medicine03 medical and health sciences

MeSH Terms

Cyclic AMPHeLa CellsHumansProtein BindingSignal TransductionMolecular ChaperonesGuanine Nucleotide Exchange Factorsrap GTP-Binding ProteinsAmino Acid Motifsrap1 GTP-Binding ProteinsSUMO-1 ProteinNuclear Pore Complex ProteinsHEK293 CellsSumoylationHela Cells

Keywords

Guanine nucleotide exchange factorNucleotideGuanineCell biologyFunction (biology)ChemistrySubcellular localizationBiologyBiochemistryComputational biologyGTPaseGeneCytoplasmcAMPNuclear envelopeNuclear pore complexsumoylationRanbp2/nup358Amino Acid MotifsSUMO-1 Proteinrap1 GTP-Binding ProteinsArticleNuclear Pore Complex ProteinsHEK293 Cellsrap GTP-Binding ProteinsCyclic AMPGuanine Nucleotide Exchange FactorsHumansResearch ArticleHeLa CellsSignal TransductionProtein BindingMolecular Chaperones

Sustainable Development Goals

SDG 0: Zero hunger