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The common homocystinuria-associated P1173L variant of human methionine synthase impairs reductive methylation

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110366Source: DataRank Database

The common homocystinuria-associated P1173L variant of human methionine synthase impairs reductive methylation is a research paper published in Journal of Biological Chemistry (2025). On theSindex it has a DataRank of 0. It has been cited 2 times.

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Open Access2 citations

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Enrichment:Funding (3 grants)Impact (FWCI 1.78)OA: goldTopics (28)IDs (PubMed, PMC, OpenAlex)Annotations (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (2)

Ruma Banerjee ORCID,Arkajit Guha

Live enrichment

PubMed:40513947 PMC:PMC12272874 OpenAlex:https://openalex.org/W4411202231

National Institute of Diabetes and Digestive and Kidney Diseases

Grant: DK45776

NIDDK NIH HHS

Grant: R01 DK045776

National Institutes of Health

FWCI

1.78

Citation Percentile

0.8%

Citation Trend

2026

goldLicense: cc-by

journalhttps://www.jbc.org/action/showPdf?pii=S0021925825022161

publisherhttps://www.jbc.org/action/showPdf?pii=S0021925825022161

publisherhttps://api.elsevier.com/content/article/PII:S0021925825022161?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925825022161?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.jbc.2025.110366

Fields of Study

Folate and B Vitamins ResearchPorphyrin Metabolism and DisordersMetabolism and Genetic Disorders

MeSH Terms

Ferredoxin-NADP ReductaseHomocystinuriaHumansKineticsMethylationNADPOxidation-ReductionS-Adenosylmethionine5-Methyltetrahydrofolate-Homocysteine S-MethyltransferaseVitamin B 12Amino Acid SubstitutionMutation, MissenseIntracellular Signaling Peptides and Proteins

Keywords

HomocystinuriaMethionine synthaseMethylationCystathionine beta synthaseMethionineHomocysteineBiochemistryChemistryBiologyGeneticsGeneAmino acid

The common homocystinuria-associated P1173L variant of human methionine synthase impairs reductive methylation

FAIR Checklist

Authors (2)

Funding (3 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)