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5hmC enhances PARP trapping and restores PARP inhibitor sensitivity in chemoresistant BRCA1/2-deficient cells

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110393Source: DataRank Database

5hmC enhances PARP trapping and restores PARP inhibitor sensitivity in chemoresistant BRCA1/2-deficient cells is a research paper published in Journal of Biological Chemistry (2025). On theSindex it has a DataRank of 0. It has been cited 3 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access3 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (2 grants)Impact (FWCI 1.91)OA: goldTopics (34)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (7)

Arun Prakash Mishra ORCID,Satheesh Kumar Sengodan ORCID,Dillon Dierman,Stephen D. Fox ORCID,Walter Chazin ORCID

Live enrichment

PubMed:40543584 PMC:PMC12281170 OpenAlex:https://openalex.org/W4411450635

NIH

Grant: R01 CA218315

National Institutes of Health National Cancer Institute

FWCI

1.91

Citation Percentile

0.9%

Citation Trend

2026

goldLicense: cc-by

journalhttps://www.jbc.org/action/showPdf?pii=S0021925825022434

publisherhttps://www.jbc.org/action/showPdf?pii=S0021925825022434

publisherhttps://api.elsevier.com/content/article/PII:S0021925825022434?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925825022434?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.jbc.2025.110393

Fields of Study

PARP inhibition in cancer therapyDNA Repair MechanismsPlant Genetic and Mutation Studies

MeSH Terms

Poly(ADP-ribose) Polymerase InhibitorsPoly (ADP-Ribose) Polymerase-1Breast NeoplasmsFemaleHumansOvarian NeoplasmsPhthalazinesPiperazinesDrug Resistance, NeoplasmBRCA1 ProteinBRCA2 ProteinCell Line, Tumor

Keywords

PARP inhibitorPoly ADP ribose polymeraseCancer researchChemistrySensitivity (control systems)Molecular biologyCell biologyBiologyDNABiochemistryPolymeraseVitamin CBRCA1BRCA2ChemoresistanceOlaparibTet Proteins5HmcTalazoparib

Sustainable Development Goals

SDG 0: Zero hunger